Clonal hematopoiesis in Philadelphia chromosome-negative bone marrow cells of chronic myeloid leukemia patients receiving dasatinib Journal Article
| Authors: | Paquette, R. L.; Nicoll, J.; Chalukya, M.; Gondek, L.; Jasek, M.; Sawyers, C. L.; Shah, N. P.; Maciejewski, J. |
| Article Title: | Clonal hematopoiesis in Philadelphia chromosome-negative bone marrow cells of chronic myeloid leukemia patients receiving dasatinib |
| Abstract: | A clonal cytogenetic abnormality was observed in Philadelphia chromosome-negative bone marrow cells of 6/27 chronic myeloid leukemia patients (+8 in 4, -7 in 1, and 20q- in 1) with dasatinib-induced remissions. The X-linked human androgen receptor gene assay demonstrated clonality in one additional patient. Single nucleotide polymorphism array analysis revealed somatic uniparental disomy involving chromosome 17(p12-pter) in another patient. The TP53 gene had a 5′ splice site deletion of exon 6 that caused alternative splicing, frame shifting and introduction of a premature stop codon. After three years, no patient developed myelodysplastic syndrome or acute myeloid leukemia. © 2009 Elsevier Ltd. |
| Keywords: | adult; clinical article; treatment outcome; aged; aged, 80 and over; middle aged; single nucleotide polymorphism; exon; frameshift mutation; gene deletion; stop codon; antineoplastic agents; follow-up studies; bone marrow cells; cytogenetics; cell differentiation; cell population; dasatinib; chronic myeloid leukemia; pyrimidines; mutational analysis; protein p53; uniparental disomy; myelodysplastic syndrome; molecular sequence data; mononuclear cell; clonal variation; base sequence; hematopoiesis; x chromosome inactivation; thiazoles; karyotype; clone cells; cytogenetic analysis; genes, p53; single nucleotide polymorphism array; tp53; philadelphia chromosome negative cell; leukemia, myeloid, chronic, atypical, bcr-abl negative; philadelphia chromosome |
| Journal Title: | Leukemia Research |
| Volume: | 34 |
| Issue: | 6 |
| ISSN: | 0145-2126 |
| Publisher: | Elsevier Ltd |
| Date Published: | 2010-06-01 |
| Start Page: | 708 |
| End Page: | 713 |
| Language: | English |
| DOI: | 10.1016/j.leukres.2009.08.032 |
| PUBMED: | 19804904 |
| PROVIDER: | scopus |
| PMCID: | PMC5821258 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: LERED" - "Source: Scopus" |
