Comparison of two treatment approaches for prostate cancer: Intensity-modulated radiation therapy combined with (125)I seed-implant brachytherapy or (125)I seed-implant brachytherapy alone Journal Article

   

Authors:	Song, Y.; Chan, M. F.; Burman, C.; Cann, D.
Article Title:	Comparison of two treatment approaches for prostate cancer: Intensity-modulated radiation therapy combined with (125)I seed-implant brachytherapy or (125)I seed-implant brachytherapy alone
Abstract:	The purpose of the present study was to assess the results of two different treatment approaches for clinically localized prostate cancer: intensity-modulated radiation therapy (IMRT) followed by 125I seed-implant brachytherapy and 125I seed-implant brachytherapy alone. We studied our 30 most recent consecutive patients. The sample population consisted of 15 cases treated with IMRT (50.4 Gy) followed by 125I seed-implant boost (95 Gy), and 15 cases treated with 125I seed implant only (144 Gy). We analyzed established dosimetric indices and various clinical parameters. In addition, we also evaluated and compared the acute urinary morbidities of the two treatment approaches, as assessed by the international prostate symptom score (IPSS). In our series, acute urinary morbidity was slightly increased with IMRT followed by 125I seed-implant brachytherapy as compared with 125I seed-implant brachytherapy alone. In addition, we observed no statistically significant correlation between the IPSS and the maximum or mean urethral dose. The combination of IMRT and seed-implant brachytherapy presents an alternative opportunity to treat clinically localized prostate cancer. The full potential of the procedure needs to be further investigated.
Keywords:	intensity modulated radiation therapy; multimodality cancer therapy; comparative study; combined modality therapy; methodology; prostatic neoplasms; radioactive iodine; iodine radioisotopes; radiotherapy, intensity-modulated; prostate tumor; scintiscanning; brachytherapy
Journal Title:	Journal of Applied Clinical Medical Physics
Volume:	9
Issue:	2
ISSN:	1526-9914
Publisher:	American College of Medical Physics
Date Published:	2008-03-18
Start Page:	2283
Language:	English
PUBMED:	18714275
PROVIDER:	scopus
DOI:	10.1120/jacmp.v9i2.2283
PMCID:	PMC5721712
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-53749107693&partnerID=40&md5=99a038a6a268cd5fcee2b10f53c610c7
Notes:	--- - "Export Date: 17 November 2011" - "Source: Scopus"

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