Development and application of Hsp90 inhibitors Journal Article

  


Authors: Solit, D. B.; Chiosis, G.
Article Title: Development and application of Hsp90 inhibitors
Abstract: Heat shock protein 90 has emerged as an important target in several diseases. The present review will discuss our understanding of the role played by Hsp90 in regulating and maintaining the transformed phenotype in cancers and neurodegenerative diseases, as well as recent findings on its roles in fungal and viral infections. It will also update the reader on the preclinical development and clinical translation of Hsp90 inhibitors. © 2007 Elsevier Ltd. All rights reserved.
Keywords: unclassified drug; acute granulocytic leukemia; clinical trial; review; monotherapy; unspecified side effect; antineoplastic agents; drug targeting; neoplasms; animals; gastrointestinal stromal tumor; melanoma; bortezomib; liver toxicity; multiple cycle treatment; breast cancer; bone marrow suppression; protein degradation; lung non small cell cancer; lung cancer; combination chemotherapy; in vivo study; antineoplastic activity; drug structure; in vitro study; chronic myeloid leukemia; drug design; drug dose escalation; lung small cell cancer; drug research; glioblastoma; lymphoma; heat shock protein 90 inhibitor; tanespimycin; heat shock protein 90; hsp90 heat-shock proteins; stomach cancer; virus infection; virus replication; kidney cancer; trastuzumab; breast metastasis; chronic lymphatic leukemia; candidiasis; antifungal agents; alzheimer disease; degenerative disease; virus diseases; myeloma; antiviral agents; nerve degeneration; tanespimycin hydroquinone; geldanamycin; radicicol; kos 1022; neurodegenerative diseases; snx 5422; alvespimycin; cnf 2024; amphotericin b; cnf 1010; mycograb
Journal Title: Drug Discovery Today
Volume: 13
Issue: 1-2
ISSN: 1359-6446
Publisher: Elsevier Inc.  
Date Published: 2008-01-01
Start Page: 38
End Page: 43
Language: English
DOI: 10.1016/j.drudis.2007.10.007
PUBMED: 18190862
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-37649024109&partnerID=40&md5=af9708b1f27ac9bea468d8eaeb51e3f5
Notes: --- - "Cited By (since 1996): 94" - "Export Date: 17 November 2011" - "CODEN: DDTOF" - "Source: Scopus"
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MSK Authors
  1. David Solit
    780 Solit
  2. Gabriela Chiosis
    279 Chiosis
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