Heat shock protein 90: Translation from cancer to Alzheimer's disease treatment? Journal Article
| Authors: | Luo, W.; Rodina, A.; Chiosis, G. |
| Article Title: | Heat shock protein 90: Translation from cancer to Alzheimer's disease treatment? |
| Abstract: | Both malignant transformation and neurodegeneration, as it occurs in Alzheimer's disease, are complex and lengthy multistep processes characterized by abnormal expression, post-translational modification, and processing of certain proteins. To maintain and allow the accumulation of these dysregulated processes, and to facilitate the step-wise evolution of the disease phenotype, cells must co-opt a compensatory regulatory mechanism. In cancer, this role has been attributed to heat shock protein 90 (Hsp90), a molecular chaperone that maintains the functional conformation of multiple proteins involved in cell-specific oncogenic processes. In this sense, at the phenotypic level, Hsp90 appears to serve as a biochemical buffer for the numerous cancer-specific lesions that are characteristic of diverse tumors. The current review proposes a similar role for Hsp90 in neurodegeneration. It will present experimentally demonstrated, but also hypothetical, roles that suggest Hsp90 can act as a regulator of pathogenic changes that lead to the neurodegenerative phenotype in Alzheimer's disease. © 2008 Luo et al; licensee BioMed Central Ltd. |
| Keywords: | mitogen activated protein kinase; protein kinase b; protein expression; acute granulocytic leukemia; gene mutation; clinical trial; pathogenesis; review; raf protein; advanced cancer; nonhuman; conference paper; pathophysiology; protein conformation; protein function; neoplasm; neoplasms; animal; metabolism; animals; unindexed drug; biological model; models, biological; protein protein interaction; lung non small cell cancer; inflammation; antineoplastic activity; abelson kinase; chronic myeloid leukemia; physiology; drug antagonism; protein processing; glycogen synthase kinase 3beta; heat shock protein 90 inhibitor; tanespimycin; heat shock protein 90; hsp90 heat-shock proteins; androgen receptor; heat shock protein 70; malignant transformation; chronic lymphatic leukemia; alzheimer disease; cd45 antigen; protein kinase zap 70; epidermal growth factor receptor kinase; amyloid precursor protein; tau protein; nerve degeneration; amyloid beta-protein; chaperone; anaplastic lymphoma kinase; cd135 antigen; amyloid beta protein; nucleophosmin; molecular chaperones; cd40 antigen; breakpoint cluster region protein; calcium calmodulin dependent protein kinase ii; casein kinase i; cd36 antigen; cyclin dependent kinase 5; heat shock protein 40; protein kinase syk; protein p25; protein p35; kennedy disease; tauopathy |
| Journal Title: | BMC Neuroscience |
| Volume: | 9 |
| Issue: | Suppl. 2 |
| ISSN: | 1471-2202 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2008-12-03 |
| Start Page: | S7 |
| Language: | English |
| DOI: | 10.1186/1471-2202-9-s3-s7 |
| PUBMED: | 19090995 |
| PROVIDER: | scopus |
| PMCID: | PMC2604891 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 15" - "Export Date: 17 November 2011" - "CODEN: BNMEA" - "Source: Scopus" |
