False-positive findings on 18F-FDG PET/CT: Differentiation of hibernoma and malignant fatty tumor on the basis of fluctuating standardized uptake values Journal Article


Authors: Smith, C. S.; Teruya-Feldstein, J.; Caravelli, J. F.; Yeung, H. W.
Article Title: False-positive findings on 18F-FDG PET/CT: Differentiation of hibernoma and malignant fatty tumor on the basis of fluctuating standardized uptake values
Abstract: Objective. Hibernoma is a benign tumor of brown fat that has imaging features similar to those of malignant fat-containing soft-tissue tumors. Hibernoma is metabolically active on 18F-FDG PET/CT, and its presence can lead to false-positive interpretations. We present three cases in which fatty lesions with increased radiotracer uptake identified on FDG PET/CT turned out to be hibernomas. The standardized uptake values of the lesions were similar to those reported in the literature for liposarcoma. However, all three patients had variable standardized uptake values over time. CONCLUSION. Variation in standardized uptake values over time is an imaging characteristic that may be helpful for differentiating hibernoma and malignant fatty tumor. © American Roentgen Ray Society.
Keywords: retrospective studies; case report; cancer staging; positron emission tomography; follow up; laboratory diagnosis; radiopharmaceuticals; computer assisted tomography; diagnosis, differential; differential diagnosis; tomography, x-ray computed; retrospective study; diagnostic agent; fluorodeoxyglucose f 18; computer assisted emission tomography; fluorodeoxyglucose f18; radiopharmaceutical agent; scintiscanning; imaging; radiography; false positive reactions; soft tissue tumor; liposarcoma; pet/ct; tomography, emission-computed; lipoma; hibernoma; neoplasms, adipose tissue
Journal Title: American Journal of Roentgenology
Volume: 190
Issue: 4
ISSN: 0361-803X
Publisher: American Roentgen Ray Society  
Date Published: 2008-04-01
Start Page: 1091
End Page: 1096
Language: English
DOI: 10.2214/ajr.07.3061
PUBMED: 18356460
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 10" - "Export Date: 17 November 2011" - "CODEN: AJROA" - "Source: Scopus"
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MSK Authors
  1. Clare Siobhan Smith
    5 Smith
  2. Julie T Feldstein
    297 Feldstein
  3. Henry W D Yeung
    126 Yeung