Polypodium leucotomos inhibits ultraviolet B radiation-induced immunosuppression Journal Article

Authors: Siscovick, J. R.; Zapolanski, T.; Magro, C.; Carrington, K.; Prograis, S.; Nussbaum, M.; Gonzalez, S.; Ding, W.; Granstein, R. D.
Article Title: Polypodium leucotomos inhibits ultraviolet B radiation-induced immunosuppression
Abstract: Background: An extract of the tropical fern Polypodium leucotomos (PL) administered orally to mice inhibits ultraviolet B (UVB) radiation-induced skin cancer formation. UVB-induced murine skin cancers occur, in part, because of UVB-induced immunosuppression. Thus, we examined whether PL inhibits UVB-suppression of the induction of contact hypersensitivity (CHS) locally or systemically. Methods: C57BL/6 mice received standard drinking water or water-containing PL. In the local model, mice were shaved on the dorsum and exposed to 3500 J/m2 of UVB radiation daily for 4 days. Control mice were not irradiated. After the last irradiation they were sensitized to oxazolone topically at the irradiated site. To examine the ability of PL to inhibit systemic UVB-induced immunosuppression, mice were given 10000 J/m2 of UVB radiation once and immunized at a non-exposed site 3 days later. Six days after immunization (in both models), mice were challenged on the ears with oxazolone and 24/48 h ear swelling assessed. Results: PL in drinking water significantly reduced the inhibition of CHS observed with exposure to UVB radiation in both the local and systemic models. Conclusions: The ability of PL to inhibit UVB radiation-induced immune suppression may explain, in part, its ability to inhibit UVR-induced skin cancer induction in mice. © Journal compilation © 2008 Blackwell Munksgaard.
Keywords: controlled study; histopathology; nonhuman; radiation dose; mouse; animals; mice; animal tissue; animal experiment; animal model; mice, inbred c57bl; radiation exposure; radiation dosage; skin; immune tolerance; immunomodulation; plant extracts; ear; immune deficiency; ultraviolet b radiation; ultraviolet rays; botanical; polypodium leucotomos extract; polypodium; swelling; immune; contac thypersensitivity; uvb radiation; oxazolone; contact allergy; light damage; provocation test; dermatitis, allergic contact; plant leaves
Journal Title: Photodermatology Photoimmunology and Photomedicine
Volume: 24
Issue: 3
ISSN: 0905-4383
Publisher: Blackwell Publishing  
Date Published: 2008-06-01
Start Page: 134
End Page: 141
Language: English
DOI: 10.1111/j.1600-0781.2008.00352.x
PUBMED: 18477132
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "CODEN: PPPHE" - "Source: Scopus"
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MSK Authors
  1. Salvador Gonzalez Rodriguez
    204 Rodriguez