Gene expression-based survival prediction in lung adenocarcinoma: A multi-site, blinded validation study Journal Article
| Authors: | Shedden, K.; Taylor, J. M. G.; Enkemann, S. A.; Tsao, M. S.; Yeatman, T. J.; Gerald, W. L.; Eschrich, S.; Jurisica, I.; Giordano, T. J.; Misek, D. E.; Chang, A. C.; Zhu, C. Q.; Strumpf, D.; Hanash, S.; Shepherd, F. A.; Ding, K.; Seymour, L.; Naoki, K.; Pennell, N.; Weir, B.; Verhaak, R.; Ladd-Acosta, C.; Golub, T.; Gruidl, M.; Sharma, A.; Szoke, J.; Zakowski, M.; Rusch, V.; Kris, M.; Viale, A.; Motoi, N.; Travis, W.; Conley, B.; Seshan, V. E.; Meyerson, M.; Kuick, R.; Dobbin, K. K.; Lively, T.; Jacobson, J. W.; Beer, D. G. |
| Article Title: | Gene expression-based survival prediction in lung adenocarcinoma: A multi-site, blinded validation study |
| Abstract: | Although prognostic gene expression signatures for survival in early-stage lung cancer have been proposed, for clinical application, it is critical to establish their performance across different subject populations and in different laboratories. Here we report a large, training-testing, multi-site, blinded validation study to characterize the performance of several prognostic models based on gene expression for 442 lung adenocarcinomas. The hypotheses proposed examined whether microarray measurements of gene expression either alone or combined with basic clinical covariates (stage, age, sex) could be used to predict overall survival in lung cancer subjects. Several models examined produced risk scores that substantially correlated with actual subject outcome. Most methods performed better with clinical data, supporting the combined use of clinical and molecular information when building prognostic models for early-stage lung cancer. This study also provides the largest available set of microarray data with extensive pathological and clinical annotation for lung adenocarcinomas. © 2008 Nature Publishing Group. |
| Keywords: | treatment outcome; major clinical study; overall survival; cancer staging; adenocarcinoma; gene expression; gene expression profiling; lung neoplasms; validation study; algorithms; risk factor; risk; gene expression regulation, neoplastic; lung adenocarcinoma; microarray analysis; oligonucleotide array sequence analysis; models, statistical; roc curve |
| Journal Title: | Nature Medicine |
| Volume: | 14 |
| Issue: | 8 |
| ISSN: | 1078-8956 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2008-08-01 |
| Start Page: | 822 |
| End Page: | 827 |
| Language: | English |
| DOI: | 10.1038/nm.1790 |
| PUBMED: | 18641660 |
| PROVIDER: | scopus |
| PMCID: | PMC2667337 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 162" - "Export Date: 17 November 2011" - "CODEN: NAMEF" - "Source: Scopus" |
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