Reflectance confocal microscopy-guided carbon dioxide laser ablation of low-risk basal cell carcinomas: A prospective study Journal Article

   


Authors: Navarrete-Dechent, C.; Cordova, M.; Liopyris, K.; Yélamos, O.; Aleissa, S.; Hibler, B.; Sierra, H.; Sahu, A.; Blank, N.; Rajadhyaksha, M.; Rossi, A.
Article Title: Reflectance confocal microscopy-guided carbon dioxide laser ablation of low-risk basal cell carcinomas: A prospective study
Abstract: Background: Basal cell carcinoma (BCC) treatment modalities can be stratified by tumor subtype and recurrence risk. The main limitation of nonsurgical treatment modalities is the lack of histopathologic confirmation. Reflectance confocal microscopy (RCM) is a noninvasive imaging device that provides quasihistologic images. Objective: To evaluate the feasibility and efficacy of RCM-guided carbon dioxide (CO2) laser ablation of low-risk BCCs. Methods: Prospective study with biopsy specimen–proven low-risk BCCs imaged with RCM. RCM was performed on these sites before and after ablation. If residual tumor was found, a new series of laser passes were performed. The patients were then monitored for recurrence clinically and with RCM. Results: Twenty-two tumor sites in 9 patients (5 men, 4 women) were imaged and treated. Median age was 59 ± 12.9 years (range, 30-74 years). Mean tumor size was 7.7 mm (range, 5-10 mm). Residual tumor was identified in 5 of 22 cases (22.7%) under RCM on immediate first-pass postablation sites, prompting additional laser passes. Median follow-up was 28.5 months (range, 22-32 months) with no recurrences found. Conclusions: Addition of RCM to laser ablation workflow can detect subclinical persistent tumor after initial ablation and may serve as an aid to increase the efficacy of laser ablation. © 2019 American Academy of Dermatology, Inc.
Keywords: treatment; reflectance confocal microscopy; basal cell carcinoma; diagnosis; follow-up; laser; ablation; carbon dioxide laser
Journal Title: Journal of the American Academy of Dermatology
Volume: 81
Issue: 4
ISSN: 0190-9622
Publisher: Mosby Elsevier  
Date Published: 2019-10-01
Start Page: 984
End Page: 988
Language: English
DOI: 10.1016/j.jaad.2019.06.014
PUBMED: 31202871
PROVIDER: scopus
PMCID: PMC6777957
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070556307&doi=10.1016%2fj.jaad.2019.06.014&partnerID=40&md5=364ddcf6269c7b6fc5d038c0a5a06718
Notes: Source: Scopus
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MSK Authors
  1. Milind Rajadhyaksha
    222 Rajadhyaksha
  2. Anthony Rossi
    233 Rossi
  3. Heidy Sierra Gil
    23 Sierra Gil
  4. Miguel A Cordova
    88 Cordova
  5. Brian Phillip Hibler
    55 Hibler
  6. Oriol Yelamos Pena
    32 Yelamos Pena
  7. Aditi Kamlesh Sahu
    30 Sahu
  8. Konstantinos Liopyris
    42 Liopyris
  9. Cristian Patricio Navarrete
    73 Navarrete
  10. Saud Aleissa
    24 Aleissa
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