Confocal microscopy to guide Erbium: yttrium aluminum garnet laser ablation of basal cell carcinoma: An ex vivo feasibility study Journal Article

   


Authors: Sierra, H.; Larson, B. A.; Chen, C. S. J.; Rajadhyaksha, M.
Article Title: Confocal microscopy to guide Erbium: yttrium aluminum garnet laser ablation of basal cell carcinoma: An ex vivo feasibility study
Abstract: For the removal of superficial and nodular basal cell carcinomas (BCCs), laser ablation provides certain advantages relative to other treatment modalities. However, efficacy and reliability tend to be variable because tissue is vaporized such that none is available for subsequent histopathological examination for residual BCC (and to confirm complete removal of tumor). Intra-operative reflectance confocal microscopy (RCM) may provide a means to detect residual tumor directly on the patient and guide ablation. However, optimization of ablation parameters will be necessary to control collateral thermal damage and preserve sufficient viability in the underlying layer of tissue, so as to subsequently allow labeling of nuclear morphology with a contrast agent and imaging of residual BCC. We report the results of a preliminary study of two key parameters (fluence, number of passes) visà- vis the feasibility of labeling and RCM imaging in human skin ex vivo, following ablation with an erbium:yttrium aluminum garnet laser. © The Authors.
Keywords: basal cell carcinoma; confocal microscopy; laser ablation
Journal Title: Journal of Biomedical Optics
Volume: 18
Issue: 9
ISSN: 1083-3668
Publisher: SPIE  
Date Published: 2013-09-01
Start Page: 095001
Language: English
DOI: 10.1117/1.jbo.18.9.095001
PROVIDER: scopus
PMCID: PMC3775678
PUBMED: 24045654
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84887867656&partnerID=40&md5=633f9be04e7f1336df295842e7fa66e5
Notes: --- - "Export Date: 2 December 2013" - "CODEN: JBOPF" - "Source: Scopus"
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MSK Authors
  1. Chih-Shan Jason Chen
    55 Chen
  2. Milind Rajadhyaksha
    223 Rajadhyaksha
  3. Bjorg Larson
    11 Larson
  4. Heidy Sierra Gil
    23 Sierra Gil
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