Towards deciphering the principles underlying an mRNA recognition code Journal Article


Authors: Serganov, A.; Patel, D. J.
Article Title: Towards deciphering the principles underlying an mRNA recognition code
Abstract: Messenger RNAs interact with a number of different molecules that determine the fate of each transcript and contribute to the overall pattern of gene expression. These interactions are governed by specific mRNA signals, which in principle could represent a special mRNA recognition 'code'. Both, small molecules and proteins demonstrate a diversity of mRNA binding modes often dependent on the structural context of the regions surrounding specific target sequences. In this review, we have highlighted recent structural studies that illustrate the diversity of recognition principles used by mRNA binders for timely and specific targeting and processing of the message. © 2008 Elsevier Ltd. All rights reserved.
Keywords: review; binding affinity; protein conformation; animals; gene expression; models, biological; genetic variability; protein interaction; rna-binding proteins; amino acid sequence; molecular sequence data; messenger rna; rna, messenger; nucleotide sequence; base sequence; crystal structure; models, molecular; binding sites; nucleic acid conformation; protein structure; rna binding; ribosome protein; rna processing, post-transcriptional; rna degradation; single stranded rna
Journal Title: Current Opinion in Structural Biology
Volume: 18
Issue: 1
ISSN: 0959-440X
Publisher: Elsevier Inc.  
Date Published: 2008-02-01
Start Page: 120
End Page: 129
Language: English
DOI: 10.1016/j.sbi.2007.12.006
PUBMED: 18255277
PROVIDER: scopus
PMCID: PMC3744885
DOI/URL:
Notes: --- - "Cited By (since 1996): 9" - "Export Date: 17 November 2011" - "CODEN: COSBE" - "Molecular Sequence Numbers: GENBANK: CA049982, GM073618;" - "Source: Scopus"
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  1. Dinshaw J Patel
    419 Patel