The long and the short of riboswitches Journal Article


Author: Serganov, A.
Article Title: The long and the short of riboswitches
Abstract: Regulatory mRNA elements or riboswitches specifically control the expression of a large number of genes in response to various cellular metabolites. The basis for selectivity of regulation is programmed in the evolutionarily conserved metabolite-sensing regions of riboswitches, which display a plethora of sequence and structural variants. Recent X-ray structures of two distinct SAM riboswitches and the sensing domains of the Mg<sup>2+</sup>, lysine, and FMN riboswitches have uncovered novel recognition principles and provided molecular details underlying the exquisite specificity of metabolite binding by RNA. These and earlier structures constitute the majority of widespread riboswitch classes and, together with riboswitch folding studies, improve our understanding of the mechanistic principles involved in riboswitch-mediated gene expression control. © 2009 Elsevier Ltd. All rights reserved.
Keywords: signal transduction; sequence analysis; review; nonhuman; genetic variability; gene expression regulation; molecular evolution; messenger rna; rna, messenger; molecular recognition; substrate specificity; ligands; crystal structure; models, molecular; nucleic acid conformation; rna structure; structure analysis; rna processing; cell metabolism; ligand binding; genetic conservation; rna metabolism; lysine; rna binding; flavine mononucleotide; magnesium ion; riboswitch
Journal Title: Current Opinion in Structural Biology
Volume: 19
Issue: 3
ISSN: 0959-440X
Publisher: Elsevier Inc.  
Date Published: 2009-06-01
Start Page: 251
End Page: 259
Language: English
DOI: 10.1016/j.sbi.2009.02.002
PUBMED: 19303767
PROVIDER: scopus
PMCID: PMC2762789
DOI/URL:
Notes: --- - "Cited By (since 1996): 26" - "Export Date: 30 November 2010" - "CODEN: COSBE" - "Source: Scopus"
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