Copper-64 trastuzumab PET imaging: A reproducibility study Journal Article
| Authors: | Carrasquillo, J. A.; Morris, P. G.; Humm, J. L.; Smith-Jones, P. M.; Beylergil, V.; Akhurst, T.; O'Donoghue, J. A.; Ruan, S.; Modi, S.; Hudis, C. A.; Larson, S. M. |
| Article Title: | Copper-64 trastuzumab PET imaging: A reproducibility study |
| Abstract: | BACKGROUND: The current study aims to assess the safety, pharmacokinetics, feasibility, and reproducibility of immunoPET imaging with copper-64 (64Cu) trastuzumab. METHODS: An IV injection of 296-370 MBq/5 mg 64Cu-trastuzumab was administered between 1 to 4 hours after routine trastuzumab treatment. Whole-body PET scans were performed immediately post-injection and at 24 hours post-injection. Serial pharmacokinetics were performed. Of 11 patients (median age of 52; range of 31-61), 8 underwent a repeat study with 64Cu-trastuzumab to assess image and pharmacokinetic reproducibility. Patients were monitored for toxicity. RESULTS: Patients experienced no allergic reactions or significant adverse effects from 64Cu-trastuzumab. Eight patients successfully completed a repeat 64Cu-trastuzumab study, with acceptable reproducibility of both the biodistribution and pharmacokinetic clearance. Study 1 versus study 2 showed similar serum concentration post-injection (mean 42.4±7.8 %ID/L vs. 44.7±12.6 %ID/L) and similar T1/2 (single exponential 46.1 vs. 44.2 hours), P>0.5. The volume of distribution (median 2.50 L) was in the range reported for trastuzumab and close to the estimated plasma volume of 2.60 L. Of 11 patients, two had 64Cu-trastuzumab localization corresponding to known tumor sites - one in liver and one in breast. CONCLUSIONS: Preliminary results suggest that scanning with 64Cu-trastuzumab is feasible, safe, and reproducible. Tumor uptake of 64Cu-trastuzumab was observed, but tumor detection exhibited low sensitivity in this study in which imaging was performed in the presence of trastuzumab therapy. |
| Journal Title: | Quarterly Journal of Nuclear Medicine and Molecular Imaging |
| Volume: | 63 |
| Issue: | 2 |
| ISSN: | 1824-4785 |
| Publisher: | Edizioni Minerva Medica |
| Date Published: | 2019-06-01 |
| Start Page: | 191 |
| End Page: | 198 |
| Language: | English |
| DOI: | 10.23736/s1824-4785.16.02867-3 |
| PUBMED: | 27171605 |
| PROVIDER: | scopus |
| PMCID: | PMC9185799 |
| DOI/URL: | |
| Notes: | Source: Scopus |
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116Morris -
905Hudis -
265Modi -
139
Akhurst -
151O'Donoghue -
433Humm -
140Carrasquillo -
67
Smith-Jones -
56Ruan -
958Larson -
25Beylergil
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