Epitope landscape in breast and colorectal cancer Journal Article
| Authors: | Segal, N. H.; Parsons, D. W.; Peggs, K. S.; Velculescu, V.; Kinzler, K. W.; Vogelstein, B.; Allison, J. P. |
| Article Title: | Epitope landscape in breast and colorectal cancer |
| Abstract: | The finding that individual cancers contain many mutant genes not present in normal tissues has prompted considerable interest in the cancer epitope landscape. To further understand such effects, we applied in silico-based epitope prediction algorithms and high throughput post hoc analysis to identify candidate tumor antigens. Analysis of 1,152 peptides containing missense mutations previously identified in breast and colorectal cancer revealed that individual cancers accumulate on average ∼10 and ∼7 novel and unique HLA-A*0201 epitopes, respectively, including genes implicated in the neoplastic process. These data suggest that, with appropriate manipulation of the immune system, tumor cell destruction in situ may provide a polyvalent tumor vaccine without a requirement for knowledge of the targeted antigens. ©2008 American Association for Cancer Research. |
| Keywords: | gene mutation; missense mutation; mutation, missense; colorectal cancer; immune system; breast cancer; peptide; breast neoplasms; algorithms; prediction; carcinogenesis; colorectal neoplasms; in situ hybridization; immune response; immunotherapy; algorithm; epitope; computer model; hla a antigen; hla-a antigens; tumor cell destruction; epitopes; post hoc analysis; peptide analysis; cancer immunology |
| Journal Title: | Cancer Research |
| Volume: | 68 |
| Issue: | 3 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2008-02-01 |
| Start Page: | 889 |
| End Page: | 892 |
| Language: | English |
| DOI: | 10.1158/0008-5472.can-07-3095 |
| PUBMED: | 18245491 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 32" - "Export Date: 17 November 2011" - "CODEN: CNREA" - "Source: Scopus" |
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