A catalytic role for proangiogenic marrow-derived cells in tumor neovascularization Journal Article
| Authors: | Seandel, M.; Butler, J.; Lyden, D.; Rafii, S. |
| Article Title: | A catalytic role for proangiogenic marrow-derived cells in tumor neovascularization |
| Abstract: | Small numbers of proangiogenic bone marrow-derived cells (BMDCs) can play pivotal roles in tumor progression. In this issue of Cancer Cell, two papers, utilizing different tumor angiogenesis models, both find that activated MMP-9 delivered by BMDCs modulates neovessel remodeling, thereby promoting tumor growth. The changes in microvascular anatomy induced by MMP-9-expressing BMDCs are strikingly different between the preirradiated tumor vascular bed model employed by Ahn and Brown and the invasive glioblastoma model utilized by Du et al., likely mirroring the complexity of the real tumor microenvironment and the intricacy of roles of different BMDC populations in mediating tumor neoangiogenesis. © 2008 Elsevier Inc. All rights reserved. |
| Keywords: | signal transduction; protein expression; nonhuman; animals; mice; mice, knockout; bone marrow cells; cell function; gelatinase b; enzyme activation; neovascularization, pathologic; time factors; cancer invasion; endothelial cells; glioblastoma; neoplasms, experimental; cell movement; stem cells; short survey; cell hypoxia; neoplasm invasiveness; bone marrow cell; catalysis; monocytes; tumor growth; bone marrow transplantation; tumor vascularization; neovascularization (pathology); hypoxia-inducible factor 1, alpha subunit; angiogenic proteins; myeloid cells; matrix metalloproteinase 9 |
| Journal Title: | Cancer Cell |
| Volume: | 13 |
| Issue: | 3 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2008-03-11 |
| Start Page: | 181 |
| End Page: | 183 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2008.02.016 |
| PUBMED: | 18328420 |
| PROVIDER: | scopus |
| PMCID: | PMC2951026 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 35" - "Export Date: 17 November 2011" - "CODEN: CCAEC" - "Source: Scopus" |
