Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007 Journal Article
| Authors: | Schwartz, G. F.; Hughes, K. S.; Lynch, H. T.; Fabian, C. J.; Fentiman, I. S.; Robson, M. E.; Domchek, S. M.; Hartmann, L. C.; Holland, R.; Winchester, D. J.; Anderson, B. O.; Arun, B. K.; Bartolink, H.; Bernard, P.; Bonanni, B.; Cady, B.; Clough, K. B.; Feig, S. A.; Heywang-Köbrunner, S. H.; Howell, A.; Isaacs, C.; Kopans, D. B.; Mansel, R. E.; Masood, S.; Palazzo, J. P.; Solin, L. J.; Untch, M. |
| Article Title: | Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007 |
| Abstract: | A consensus conference including 30 experts was held in April, 2007, to discuss risk factors for breast cancer and their management. Four categories of risk were outlined, from "average" through "very high" risk, the latter including individuals with high penetrance BRCA1/2 gene mutations. Guidelines for management of patients in each of these categories were discussed, with the major portion of the conference devoted to individuals with BRCA1/2 mutations. Prevalence of these mutations in the general population was estimated to be 1 in 250-500 individuals, with an increased prevalence in Ashkenazi Jews and other founder groups. Risk-reduction strategies for these individuals included surveillance, with or without chemoprevention drugs, or surgical procedures to remove the organs at risk, ie, bilateral mastectomy and/or bilateral salpingo-oophorectomy. These risk reduction strategies were evaluated fully, and recommendations were made for the care of patients in each risk category. These guidelines for patient care were approved by the entire group of experts. © 2008 American Cancer Society. |
| Keywords: | gene mutation; mutation; cancer risk; conference paper; cancer staging; nuclear magnetic resonance imaging; follow up; sentinel lymph node biopsy; genetic predisposition to disease; consensus; quality of life; ovary cancer; breast cancer; mastectomy; ovariectomy; prevalence; risk factors; practice guideline; breast neoplasms; brca1 protein; brca2 protein; risk factor; risk assessment; oncogene; patient care; mammography; genes, brca1; genes, brca2; prophylaxis; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; tamoxifen; risk reduction; health care organization; genetic screening; oral contraceptive agent; patient counseling; hormone substitution; risk management; brca mutations; international conference; patient management guidelines |
| Journal Title: | Cancer |
| Volume: | 113 |
| Issue: | 10 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2008-11-15 |
| Start Page: | 2627 |
| End Page: | 2637 |
| Language: | English |
| DOI: | 10.1002/cncr.23903 |
| PUBMED: | 18853415 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 18" - "Export Date: 17 November 2011" - "CODEN: CANCA" - "Source: Scopus" |
