Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007 Journal Article
| Authors: | Schwartz, G. F.; Hughes, K. S.; Lynch, H. T.; Fabian, C. J.; Fentiman, I. S.; Robson, M. E.; Domchek, S. M.; Hartmann, L. C.; Holland, R.; Winchester, D. J.; Anderson, B. O.; Arun, B. K.; Bartelink, H.; Bernard, P.; Bonanni, B.; Cady, B.; Clough, K. B.; Feig, S. A.; Heywang-Köbrunner, S. H.; Howell, A.; Isaacs, C.; Kopans, D. B.; Mansel, R. E.; Masood, S.; Palazzo, J. P.; Pressman, P. I.; Solin, L. J.; Untch, M. |
| Article Title: | Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007 |
| Abstract: | A consensus conference including thirty experts was held in April, 2007, to discuss risk factors for breast cancer and their management. Four categories of risk were outlined, from breast cancer "average" through "very high" risk, the latter including individuals with high penetrance BRCA1/2 gene mutations. Guidelines for management of patients in each of these categories were discussed, with the major portion of the conference being devoted to individuals with BRCA1/2 mutations. Prevalence of these mutations in the general populations was estimated to be 1 in 250-500 individuals, with an increased prevalence in Ashkenazic Jews and other founder groups. Risk reduction strategies for these individuals include surveillance, with or without chemoprevention drugs, or surgical procedures to remove the organs at risk, i.e., bilateral mastectomy and/or bilateral salpingo-oophorectomy. These risk reduction strategies were evaluated fully, and recommendations were made for the care of patients in each of the risk categories. These guidelines for patient care were approved by the entire group of experts. © 2008 Wiley Periodicals, Inc. |
| Keywords: | cancer surgery; surgical technique; gene mutation; genetics; mutation; cancer risk; conference paper; nuclear magnetic resonance imaging; cancer diagnosis; salpingooophorectomy; cytology; cancer prevention; chemoprophylaxis; quality of life; ovary cancer; breast cancer; mastectomy; prevalence; estrogen; risk factors; practice guideline; tumor biopsy; breast neoplasms; brca1 protein; brca2 protein; risk factor; risk assessment; risk; cancer genetics; oncogene; patient care; estrogen replacement therapy; mammography; genes, brca1; genes, brca2; family history; pten phosphohydrolase; tamoxifen; cancer epidemiology; high risk population; risk reduction; brca; breast surgery; oral contraceptive agent; genetic counseling; genes, p53; hormone substitution; risk management; penetrance; raloxifene; bacterial gene |
| Journal Title: | Breast Journal |
| Volume: | 15 |
| Issue: | 1 |
| ISSN: | 1075-122X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2009-01-01 |
| Start Page: | 4 |
| End Page: | 16 |
| Language: | English |
| DOI: | 10.1111/j.1524-4741.2008.00665.x |
| PUBMED: | 19141130 |
| PROVIDER: | scopus |
| PMCID: | PMC3756316 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 30 November 2010" - "CODEN: BRJOF" - "Source: Scopus" |
