Comparison of radiotherapy strategies for locally advanced hypopharyngeal cancer after resection and ileocolic flap reconstruction Journal Article
| Authors: | Tai, H. C.; Hsieh, C. H.; Chao, K. C.; Liu, S. H.; Leu, Y. S.; Chang, Y. F.; Hsiao, H. T.; Chang, Y. C.; Huang, D. Y. C.; Chen, Y. J. |
| Article Title: | Comparison of radiotherapy strategies for locally advanced hypopharyngeal cancer after resection and ileocolic flap reconstruction |
| Abstract: | Conclusion. IMRT provided better conformity, less toxicity and better function restoration for advanced hypopharyngeal carcinoma after major surgery with ileocolic flap reconstruction. Objectives. To compare the results of adjuvant conventional radiotherapy (2DRT) with intensity modulated radiation therapy (IMRT) for locally advanced hypopharyngeal cancer after resection and ileocolic free flap reconstruction and to design treatment plans for those two modalities plus 3D conformal radiotherapy (3DCRT) for dose distribution comparison. Methods. 13 locally advanced hypopharyngeal cancer patients were enrolled, 8 treated with 2DRT and 5 with IMRT. Different plans were planned for 3 IMRT-treated patients for comparing dose distribution. Results. After major surgery, patients treated with IMRT had less toxicity and better functional restoration than those with 2DRT. IMRT and 3DCRT both showed lower dose to the spinal cord than did 2DRT. Only IMRT showed reduced dose to ileocolic flap. © 2009 Informa UK Ltd. (Informa Healthcare, Taylor & Francis As). |
| Keywords: | adult; clinical article; controlled study; treatment outcome; middle aged; cancer surgery; retrospective studies; intensity modulated radiation therapy; carcinoma, squamous cell; surgical flaps; cisplatin; fluorouracil; advanced cancer; cancer combination chemotherapy; multimodality cancer therapy; cancer adjuvant therapy; cancer patient; cancer radiotherapy; radiation dose; radiotherapy, adjuvant; multiple cycle treatment; continuous infusion; dose-response relationship, radiation; radiotherapy, intensity-modulated; spinal cord; intermethod comparison; radiotherapy, conformal; computer assisted radiotherapy; radiation dose distribution; functional status; 3d conformal radiotherapy; hypopharyngeal cancer; ileocolic flap; hypopharynx carcinoma; tissue flap; hypopharyngeal neoplasms |
| Journal Title: | Acta Oto-Laryngologica |
| Volume: | 129 |
| Issue: | 3 |
| ISSN: | 0001-6489 |
| Publisher: | Informa Healthcare |
| Date Published: | 2009-03-01 |
| Start Page: | 311 |
| End Page: | 317 |
| Language: | English |
| DOI: | 10.1080/00016480802163366 |
| PUBMED: | 18607975 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 30 November 2010" - "CODEN: AOLAA" - "Source: Scopus" |
