Dosimetric comparison of axilla and groin radiotherapy techniques for high-risk and locally advanced skin cancer Journal Article
| Authors: | Mattes, M. D.; Zhou, Y.; Berry, S. L.; Barker, C. A. |
| Article Title: | Dosimetric comparison of axilla and groin radiotherapy techniques for high-risk and locally advanced skin cancer |
| Abstract: | Purpose: Radiation therapy targeting axilla and groin lymph nodes improves regional disease control in locally advanced and high-risk skin cancers. However, trials generally used conventional two-dimensional radiotherapy (2D-RT), contributing towards relatively high rates of side effects from treatment. The goal of this study is to determine if three-dimensional conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT), or volumetric-modulated arc therapy (VMAT) may improve radiation delivery to the target while avoiding organs at risk in the clinical context of skin cancer regional nodal irradiation. Materials and Methods: Twenty patients with locally advanced/high-risk skin cancers underwent computed tomography simulation. The relevant axilla or groin planning target volumes and organs at risk were delineated using standard definitions. Paired t-tests were used to compare the mean values of several dose-volumetric parameters for each of the 4 techniques. Results: In the axilla, the largest improvement for 3D-CRT compared to 2D-RT was for homogeneity index (13.9 vs. 54.3), at the expense of higher lung V 20 (28.0% vs. 12.6%). In the groin, the largest improvements for 3D-CRT compared to 2D-RT were for anorectum Dmax (13.6 vs. 38.9 Gy), bowel D 200cc (7.3 vs. 23.1 Gy), femur D 50 (34.6 vs. 57.2 Gy), and genitalia Dmax (37.6 vs. 51.1 Gy). IMRT had further improvements compared to 3D-CRT for humerus Dmean (16.9 vs. 22.4 Gy), brachial plexus D 5 (57.4 vs. 61.3 Gy), bladder D5 (26.8 vs. 36.5 Gy), and femur D50 (18.7 vs. 34.6 Gy). Fewer differences were observed between IMRT and VMAT. Conclusion: Compared to 2D-RT and 3D-CRT, IMRT and VMAT had dosimetric advantages in the treatment of nodal regions of skin cancer patients. © 2016. The Korean Society for Radiation Oncology. |
| Keywords: | squamous cell carcinoma; melanoma; intensity-modulated radiotherapy; merkel cell carcinoma; conformal radiotherapy; skin neoplasm |
| Journal Title: | Radiation Oncology Journal |
| Volume: | 34 |
| Issue: | 2 |
| ISSN: | 2234-1900 |
| Publisher: | The Korean Society for Radiation Oncology |
| Date Published: | 2016-06-01 |
| Start Page: | 145 |
| End Page: | 155 |
| Language: | English |
| DOI: | 10.3857/roj.2015.01592 |
| PROVIDER: | scopus |
| PMCID: | PMC4938352 |
| PUBMED: | 27306779 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 August 2016 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work