Cloning of a D-type cyclin from murine erythroleukemia cells Journal Article
| Authors: | Kiyokawa, H.; Busquets, X.; Powell, C. T.; Ngo, L.; Rifkind, R. A.; Marks, P. A. |
| Article Title: | Cloning of a D-type cyclin from murine erythroleukemia cells |
| Abstract: | We report the complete coding sequence of a cDNA, designated CYL2, derived from a murine erythroleukemia cell library. CYL2 is considered to encode a D-type cyclin because (i) there is cross hybridization with CYL1 (a murine homolog of human cyclin D1) and the encoded protein has 64% amino acid sequence identity with CYL1 and (ii) murine erythroleukemia cell-derived CYL2 contains an amino acid sequence identical to that previously reported for the C-terminal portion of a partially sequenced CYL2. Transcripts of murine erythroleukemia cell CYL2 undergo alternative polyadenylylation like that of human cyclin D1. A major 6.5-kilobase CYL2 transcript changes its expression during the cell cycle with a broad peak through G1 and S phases and a decrease in G2/M phases. The present findings suggest that CYL2 plays a role in the G1 to S phase progression. |
| Keywords: | gene; cell cycle; phosphorylation; saccharomyces-cerevisiae; activation; messenger-rna; fission yeast; protein-kinase; cdc2; g1; m-phase; cyl2 cdna |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 89 |
| Issue: | 6 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 1992-03-15 |
| Start Page: | 2444 |
| End Page: | 2447 |
| Language: | English |
| ACCESSION: | WOS:A1992HJ05300092 |
| DOI: | 10.1073/pnas.89.6.2444 |
| PROVIDER: | wos |
| PMCID: | PMC48674 |
| PUBMED: | 1372445 |
| Notes: | Article -- Source: Wos |
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