The cancer biomarker problem Journal Article
| Author: | Sawyers, C. L. |
| Article Title: | The cancer biomarker problem |
| Abstract: | Genomic technologies offer the promise of a comprehensive understanding of cancer. These technologies are being used to characterize tumours at the molecular level, and several clinical successes have shown that such information can guide the design of drugs targeted to a relevant molecule. One of the main barriers to further progress is identifying the biological indicators, or biomarkers, of cancer that predict who will benefit from a particular targeted therapy. ©2008 Nature Publishing Group. |
| Keywords: | review; nonhuman; solid tumor; chemotherapy; neoplasm; neoplasms; biological marker; gene expression; tumor markers, biological; cancer screening; drug development; mutational analysis; proteomics; cancer genetics; biomarker; molecular analysis; genomics; pharmacogenetics; tumor; dna determination; metabolomics |
| Journal Title: | Nature |
| Volume: | 452 |
| Issue: | 7187 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2008-04-03 |
| Start Page: | 548 |
| End Page: | 552 |
| Language: | English |
| DOI: | 10.1038/nature06913 |
| PUBMED: | 18385728 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 152" - "Export Date: 17 November 2011" - "CODEN: NATUA" - "Source: Scopus" |
