Applications of pHLIP technology for cancer imaging and therapy Journal Article
| Authors: | Wyatt, L. C.; Lewis, J. S.; Andreev, O. A.; Reshetnyak, Y. K.; Engelman, D. M. |
| Article Title: | Applications of pHLIP technology for cancer imaging and therapy |
| Abstract: | Acidity is a biomarker of cancer that is not subject to the blunting clonal selection effects that reduce the efficacy of other biomarker technologies, such as antibody targeting. The pH (low) insertion peptides (pHLIP®s) provide new opportunities for targeting acidic tissues. Through the physical mechanism of membrane-associated folding, pHLIPs are triggered by the acidic microenvironment to insert and span the membranes of tumor cells. The pHLIP platform can be applied to imaging acidic tissues, delivering cell-permeable and impermeable molecules to the cytoplasm, and promoting the cellular uptake of nanoparticles. Since acidosis is a hallmark of tumor development, progression, and aggressiveness, the pHLIP technology may prove useful in targeting cancer cells and metastases for tumor diagnosis, imaging, and therapy. © 2017 Elsevier Ltd |
| Keywords: | biomarkers; cytology; pathology; enzyme activity; diagnostic imaging; histology; tumor targeting; medical imaging; tumors; diagnosis; imaging; diseases; tissue; nanotechnology; drug delivery; acidity; cells; medical applications; imaging techniques; clinical translation; intracellular delivery; therapeutic agents; physical mechanism; acidic environment; acidic microenvironment |
| Journal Title: | Trends in Biotechnology |
| Volume: | 35 |
| Issue: | 7 |
| ISSN: | 0167-7799 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2017-07-01 |
| Start Page: | 653 |
| End Page: | 664 |
| Language: | English |
| DOI: | 10.1016/j.tibtech.2017.03.014 |
| PROVIDER: | scopus |
| PUBMED: | 28438340 |
| PMCID: | PMC5492987 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 July 2017 -- Source: Scopus |
