Synergistic inhibition of replication of human immunodeficiency virus type 1, including that of a zidovudine-resistant isolate, by zidovudine and 2',3'-dideoxycytidine in vitro Journal Article
| Authors: | Eron, J. J. Jr; Johnson, V. A.; Merrill, D. P.; Chou, T. C.; Hirsch, M. S. |
| Article Title: | Synergistic inhibition of replication of human immunodeficiency virus type 1, including that of a zidovudine-resistant isolate, by zidovudine and 2',3'-dideoxycytidine in vitro |
| Abstract: | The combination of zidovudine (AZT) and 2',3'-dideoxycytidine synergistically inhibits human immunodeficiency virus type 1 (HIV-1) replication in vitro with AZT-sensitive and AZT-resistant clinical isolates and HIV-1IIIB. Synergy was,determined by the median-effect principle and isobologram techniques. Cytotoxicity of the agents was not observed. Clinical trials are ongoing to define the combination's role in HIV-1 therapy. |
| Keywords: | infection; therapy; placebo-controlled trial; double-blind; phase-i trial; azidothymidine; aids-related complex; azt; 2',3'-dideoxyinosine ddi; 2',3'-dideoxynucleosides |
| Journal Title: | Antimicrobial Agents and Chemotherapy |
| Volume: | 36 |
| Issue: | 7 |
| ISSN: | 0066-4804 |
| Publisher: | American Society for Microbiology |
| Date Published: | 1992-07-01 |
| Start Page: | 1559 |
| End Page: | 1562 |
| Language: | English |
| ACCESSION: | WOS:A1992JC89400036 |
| DOI: | 10.1128/aac.36.7.1559 |
| PROVIDER: | wos |
| PMCID: | PMC191620 |
| PUBMED: | 1324648 |
| Notes: | Source: Wos |
