Priming of protective T cell responses against virus-induced tumors in mice with human immune system components Journal Article
| Authors: | Strowig, T.; Gurer, C.; Ploss, A.; Liu, Y. F.; Arrey, F.; Sashihara, J.; Koo, G.; Rice, C. M.; Young, J. W.; Chadburn, A.; Cohen, J. I.; Münz, C. |
| Article Title: | Priming of protective T cell responses against virus-induced tumors in mice with human immune system components |
| Abstract: | Many pathogens that cause human disease infect only humans. To identify the mechanisms of immune protection against these pathogens and also to evaluate promising vaccine candidates, a small animal model would be desirable. We demonstrate that primary T cell responses in mice with reconstituted human immune system components control infection with the oncogenic and persistent Epstein-Barr virus (EBV). These cytotoxic and interferon-γ-producing T cell responses were human leukocyte antigen (HLA) restricted and specific for EBV-derived peptides. In HLA-A2 transgenic animals and similar to human EBV carriers, T cell responses against lytic EBV antigens dominated over recognition of latent EBV antigens. T cell depletion resulted in elevated viral loads and emergence of EBV-associated lymphoproliferative disease. Both loss of CD4 <sup>+</sup> and CD8<sup>+</sup> T cells abolished immune control. Therefore, this mouse model recapitulates features of symptomatic primary EBV infection and generates T cell-mediated immune control that resists oncogenic transformation. © 2009 Strowig et al. |
| Keywords: | controlled study; nonhuman; neoplasms; cd8+ t lymphocyte; t lymphocyte; t-lymphocytes; mouse; animals; mice; mice, knockout; animal tissue; immune system; spleen; animal experiment; animal model; mice, scid; mice, transgenic; kidney; cellular immunity; gamma interferon; cd4+ t lymphocyte; lymphoproliferative disease; virus load; disease models, animal; t cell depletion; mice, inbred nod; cell protection; herpes; epstein barr virus; herpesvirus 4, human; hla system; hla a2 antigen; virus carrier; virus isolation; epstein-barr virus infections; hla-a2 antigen |
| Journal Title: | Journal of Experimental Medicine |
| Volume: | 206 |
| Issue: | 6 |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Date Published: | 2009-06-08 |
| Start Page: | 1423 |
| End Page: | 1434 |
| Language: | English |
| DOI: | 10.1084/jem.20081720 |
| PUBMED: | 19487422 |
| PROVIDER: | scopus |
| PMCID: | PMC2715061 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 13" - "Export Date: 30 November 2010" - "CODEN: JEMEA" - "Source: Scopus" |
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