Seeding and propagation of untransformed mouse mammary cells in the lung Journal Article
| Authors: | Podsypanina, K.; Du, Y. C. N.; Jechlinger, M.; Beverly, L. J.; Hambardzumyan, D.; Varmus, H. |
| Article Title: | Seeding and propagation of untransformed mouse mammary cells in the lung |
| Abstract: | The acquisition of metastatic ability by tumor cells is considered a late event in the evolution of malignant tumors. We report that untransformed mouse mammary cells that have been engineered to express the inducible oncogenic transgenes MYC and KrasD12, or polyoma middle T, and introduced into the systemic circulation of a mouse can bypass transformation at the primary site and develop into metastatic pulmonary lesions upon immediate or delayed oncogene induction. Therefore, previously untransformed mammary cells may establish residence in the lung once they have entered the bloodstream and may assume malignant growth upon oncogene activation. Mammary cells lacking oncogenic transgenes displayed a similar capacity for long-term residence in the lungs but did not form ectopic tumors. |
| Keywords: | cancer growth; nonhuman; adenocarcinoma; cell proliferation; animal cell; mouse; cytology; animals; mice; animal tissue; cell survival; gene expression; lung neoplasms; animal experiment; animal model; lung cancer; carcinogenesis; mice, transgenic; cell transformation, neoplastic; oncogenes; lung metastasis; gene activation; gene expression regulation, neoplastic; cell transformation; genes, myc; neoplasm metastasis; transgene; epithelial cells; gene induction; oncogene k ras; genes, ras; tumor; respiration; antigens, polyomavirus transforming; mammary glands, animal; oncogene myc; breast cell; transgenes; mammary neoplasms, experimental; neoplasm seeding; virus middle t antigen; neoplasm circulating cells |
| Journal Title: | Science |
| Volume: | 321 |
| Issue: | 5897 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2008-09-26 |
| Start Page: | 1841 |
| End Page: | 1844 |
| Language: | English |
| DOI: | 10.1126/science.1161621 |
| PUBMED: | 18755941 |
| PROVIDER: | scopus |
| PMCID: | PMC2694414 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 95" - "Export Date: 17 November 2011" - "CODEN: SCIEA" - "Source: Scopus" |
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