MRI and PET/MRI in hematologic malignancies Review
| Authors: | Mayerhoefer, M. E.; Archibald, S. J.; Messiou, C.; Staudenherz, A.; Berzaczy, D.; Schòˆder, H. |
| Review Title: | MRI and PET/MRI in hematologic malignancies |
| Abstract: | The role of MRI differs considerably between the three main groups of hematological malignancies: lymphoma, leukemia, and myeloma. In myeloma, whole-body MRI (WB-MRI) is recognized as a highly sensitive test for the assessment of myeloma, and is also endorsed by clinical guidelines, especially for detection and staging. In lymphoma, WB-MRI is presently not recommended, and merely serves as an alternative technique to the current standard imaging test, [F-18]FDG-PET/CT, especially in pediatric patients. Even for lymphomas with variable FDG avidity, such as extranodal mucosa-associated lymphoid tissue lymphoma (MALT), contrast-enhanced computed tomography (CT), but not WB-MRI, is presently recommended, despite the high sensitivity of diffusion-weighted MRI and its ability to capture treatment response that has been reported in the literature. In leukemia, neither MRI nor any other cross-sectional imaging test (including positron emission tomography [PET]) is currently recommended outside of clinical trials. This review article discusses current clinical applications as well as the main research topics for MRI, as well as PET/MRI, in the field of hematological malignancies, with a focus on functional MRI techniques such as diffusion-weighted imaging and dynamic contrast-enhanced MRI, on the one hand, and novel, non-FDG PET imaging probes such as the CXCR4 radiotracer [Ga-68]Ga-Pentixafor and the amino acid radiotracer [C-11]methionine, on the other hand. Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2019. |
| Keywords: | leukemia; minimal residual disease; lymphoma; pet; mri; myeloma; diffusion-weighted mri; response assessment; positron-emission-tomography; non-hodgkin-lymphoma; magnetic-resonance; acute myeloid-leukemia; metabolic tumor volume; whole-body mri; bone-marrow angiogenesis |
| Journal Title: | Journal of Magnetic Resonance Imaging |
| Volume: | 51 |
| Issue: | 5 |
| ISSN: | 1053-1807 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2020-05-01 |
| Start Page: | 1325 |
| End Page: | 1335 |
| Language: | English |
| ACCESSION: | WOS:000477369600001 |
| DOI: | 10.1002/jmri.26848 |
| PROVIDER: | wos |
| PUBMED: | 31260155 |
| PMCID: | PMC7217155 |
| Notes: | Review -- Source: Wos |
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