Bleeding disorders associated with cancer Journal Article
| Author: | Mantha, S. |
| Article Title: | Bleeding disorders associated with cancer |
| Abstract: | Cancer can be associated with several distinct coagulation defects which can lead to bleeding complications. The primary hyperfibrinolytic syndrome associated with acute promyelocytic leukemia has been well recognized and is one of the most severe bleeding disorders. Acquired hemophilia, while rare and not only seen in the oncology setting, can be triggered by a malignancy and must be promptly recognized in order to prevent catastrophic hemorrhage. Other, less serious coagulopathic states have been linked to cancer, including acquired von Willebrand disease. Finally, several anti-neoplastic drugs can alter hemostasis and increase the risk of bleeding. A good understanding of this field can help mitigate the risk of complications in the cancer patient. © Springer Nature Switzerland AG 2019. |
| Keywords: | sorafenib; bevacizumab; erlotinib; sunitinib; rituximab; disease association; mantle cell lymphoma; bleeding; cyclophosphamide; amyloidosis; hyperviscosity syndrome; plasmapheresis; waldenstroem macroglobulinemia; drug effect; myelodysplastic syndrome; gefitinib; promyelocytic leukemia; pazopanib; vandetanib; axitinib; corticosteroid; chronic lymphatic leukemia; retinoic acid; hemophilia; acute promyelocytic leukemia; leukapheresis; bone marrow tumor; hemorrhage; prothrombin complex; thrombocyte aggregation; bleeding disorder; disseminated intravascular clotting; ibrutinib; regorafenib; leukostasis; cancer; human; priority journal; recombinant blood clotting factor 8; malignant neoplasm; von willebrand disease; acquired hemophilia; acquired von willebrand disease; hyperfibrinolytic syndrome |
| Journal Title: | Cancer Treatment and Research |
| Volume: | 179 |
| ISSN: | 0927-3042 |
| Publisher: | Springer |
| Date Published: | 2019-01-01 |
| Start Page: | 191 |
| End Page: | 203 |
| Language: | English |
| DOI: | 10.1007/978-3-030-20315-3_13 |
| PUBMED: | 31317489 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Chapter 13 in "Thrombosis and Hemostasis in Cancer" (ISBN: 978-3-030-20314-6) -- Source: Scopus |
