Growth hormone and insulin reverse net whole body and skeletal muscle protein catabolism in cancer patients Conference Paper


Authors: Wolf, R. F.; Pearlstone, D. B.; Newman, E.; Heslin, M. J.; Gonenne, A.; Burt, M. E.; Brennan, M. F.
Title: Growth hormone and insulin reverse net whole body and skeletal muscle protein catabolism in cancer patients
Conference Title: 112th Annual Meeting of the American Surgical Association (ASA)
Abstract: The authors examined the effect of recombinant-human growth hormone (r- hGH) and insulin (INS) administration on protein kinetics in cancer patients. Twenty-eight cancer patients either received r-hGH for 3 days (GH group, n = 12, weight loss = 6 ± 2%) or were not treated (control [CTL] group, n = 16, weight loss = 11 ± 2%) before metabolic study. Recombinant-human growth hormone dose was 0.1 mg/kg/day (n = 6) or 0.2 mg/kg/day (n = 6). Patients then underwent measurement of baseline protein kinetics (GH/B, CTL/B) followed by a 2-hour euglycemic insulin infusion (1 mU/kg/minute) and repeat kinetic measurements (GH/INS,CTL/INS). Whole-body protein net balance (μmol leucine/kg/minute) was higher (p < 0.05) in GH/INS (0.20 ± 0.06) than in CTL/INS (0.06 ± 0.03) or GH/B (-0.19 ± 0.03). Skeletal muscle protein net balance (nmol phenylalanine/100 g/minute) in GH/INS (25 ± 6) and CTL/INS (19 ± 5) was higher than CTL/B (-18 ± 3). Recombinant-human growth hormone and insulin reduce whole-body and skeletal muscle protein loss in cancer patients. Simultaneous use of these agents during nutritional therapy may benefit the cancer patient.
Keywords: adult; clinical article; controlled study; conference paper; cancer patient; protein degradation; protein depletion; protein metabolism; lung cancer; digestive system cancer; insulin; glucose blood level; insulin blood level; amino acid blood level; cachexia; somatomedin c; kidney cancer; skeletal muscle; anthropometric parameters; growth hormone blood level; human; male; female; priority journal; insulin infusion; glucagon blood level; somatrem; carbon dioxide measurement
Journal Title Annals of Surgery
Volume: 216
Issue: 3
Conference Dates: 1992 Apr 6-8
Conference Location: Palm Desert, CA
ISBN: 0003-4932
Publisher: Lippincott Williams & Wilkins  
Date Published: 1992-09-01
Start Page: 280
End Page: 288; discussion 288-290
Language: English
DOI: 10.1097/00000658-199209000-00007
PUBMED: 1417177
PROVIDER: scopus
PMCID: PMC1242608
DOI/URL:
Notes: Conference Paper -- Source: Scopus
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MSK Authors
  1. Murray F Brennan
    1059 Brennan
  2. Michael E. Burt
    187 Burt
  3. Martin J. Heslin
    30 Heslin
  4. Elliot Newman
    19 Newman
  5. Ronald F. Wolf
    15 Wolf