Growth hormone and insulin reverse net whole body and skeletal muscle protein catabolism in cancer patients Conference Paper
| Authors: | Wolf, R. F.; Pearlstone, D. B.; Newman, E.; Heslin, M. J.; Gonenne, A.; Burt, M. E.; Brennan, M. F. |
| Title: | Growth hormone and insulin reverse net whole body and skeletal muscle protein catabolism in cancer patients |
| Conference Title: | 112th Annual Meeting of the American Surgical Association (ASA) |
| Abstract: | The authors examined the effect of recombinant-human growth hormone (r- hGH) and insulin (INS) administration on protein kinetics in cancer patients. Twenty-eight cancer patients either received r-hGH for 3 days (GH group, n = 12, weight loss = 6 ± 2%) or were not treated (control [CTL] group, n = 16, weight loss = 11 ± 2%) before metabolic study. Recombinant-human growth hormone dose was 0.1 mg/kg/day (n = 6) or 0.2 mg/kg/day (n = 6). Patients then underwent measurement of baseline protein kinetics (GH/B, CTL/B) followed by a 2-hour euglycemic insulin infusion (1 mU/kg/minute) and repeat kinetic measurements (GH/INS,CTL/INS). Whole-body protein net balance (μmol leucine/kg/minute) was higher (p < 0.05) in GH/INS (0.20 ± 0.06) than in CTL/INS (0.06 ± 0.03) or GH/B (-0.19 ± 0.03). Skeletal muscle protein net balance (nmol phenylalanine/100 g/minute) in GH/INS (25 ± 6) and CTL/INS (19 ± 5) was higher than CTL/B (-18 ± 3). Recombinant-human growth hormone and insulin reduce whole-body and skeletal muscle protein loss in cancer patients. Simultaneous use of these agents during nutritional therapy may benefit the cancer patient. |
| Keywords: | adult; clinical article; controlled study; conference paper; cancer patient; protein degradation; protein depletion; protein metabolism; lung cancer; digestive system cancer; insulin; glucose blood level; insulin blood level; amino acid blood level; cachexia; somatomedin c; kidney cancer; skeletal muscle; anthropometric parameters; growth hormone blood level; human; male; female; priority journal; insulin infusion; glucagon blood level; somatrem; carbon dioxide measurement |
| Journal Title | Annals of Surgery |
| Volume: | 216 |
| Issue: | 3 |
| Conference Dates: | 1992 Apr 6-8 |
| Conference Location: | Palm Desert, CA |
| ISBN: | 0003-4932 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1992-09-01 |
| Start Page: | 280 |
| End Page: | 288; discussion 288-290 |
| Language: | English |
| DOI: | 10.1097/00000658-199209000-00007 |
| PUBMED: | 1417177 |
| PROVIDER: | scopus |
| PMCID: | PMC1242608 |
| DOI/URL: | |
| Notes: | Conference Paper -- Source: Scopus |
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