Review of regional therapy of liver metastases in colorectal cancer Journal Article
| Author: | Kemeny, N. |
| Article Title: | Review of regional therapy of liver metastases in colorectal cancer |
| Abstract: | Hepatic metastases are a major cause of mortality in patients with colorectal carcinoma. The rationale for regional therapy is presented. The randomized studies are reviewed and they demonstrated a significantly higher response rate with hepatic arterial therapy versus systemic therapy. Survival information is difficult to evaluate because some of the studies are small and some had a crossover design, but two studies demonstrate a significant inprovement in 2-year survival after hepatic arterial therapy versus systemic therapy. New modalities to increase response rate and decrease toxicity are presented. © 1992. |
| Keywords: | cancer survival; review; fluorouracil; diarrhea; liver neoplasms; colorectal cancer; liver toxicity; dexamethasone; colorectal neoplasms; aspartate aminotransferase; liver metastasis; cancer regression; randomized controlled trials; folinic acid; intraarterial drug administration; regional perfusion; infusions, intra-arterial; liver enzyme; floxuridine; leucovorin; cholecystitis; hepatic artery; intravenous drug administration; liver function tests; gastritis; peptic ulcer; sclerosing cholangitis; infusion pumps; human; priority journal |
| Journal Title: | Seminars in Oncology |
| Volume: | 19 |
| Issue: | 2 Suppl. 3 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1992-04-01 |
| Start Page: | 155 |
| End Page: | 162 |
| Language: | English |
| PUBMED: | 1532670 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 30 July 2019 -- Source: Scopus |
