Cancer vaccines: An overview Journal Article
| Author: | Old, L. J. |
| Article Title: | Cancer vaccines: An overview |
| Abstract: | The long-held hope that vaccination strategies might be effective against cancer has motivated numerous attempts over the past century to put the idea to test in the clinic. Although the generally disappointing results have cast a long shadow over the field, advances in cancer immunology growing on the remarkable insights from basic immunology provide a strong foundation and powerful new tools to guide current attempts to fashion effective cancer vaccines. This review covers the scientific basis and rationale for cancer vaccines, the challenges involved in assembling the many ingredients going into the construction of cancer vaccines, and the daunting obstacles confronting academic investigators wanting to transfer their discoveries into the clinical arena. The Cancer Vaccine Collaborative (CVC), a partnership between the Cancer Research Institute and the Ludwig Institute for Cancer Research, represents a new academic model for developing, coordinating, conducting, and monitoring cancer vaccine trial. NY-ESO-1, a prototype cancer-testis (CT) antigen having strong spontaneous humoral and cellular immunogenicity, has been chosen as the initial CVC vaccine target, and the current status of NY-ESO-1 vaccine trials carried at the multiple CVC sites around the world is discussed. Copyright © 2008 by Lloyd J. Old. |
| Keywords: | clinical trial; review; clinical trials as topic; human immunodeficiency virus infection; neoplasm; neoplasms; animal; animals; cytotoxic t lymphocyte antigen 4 antibody; cancer prevention; lung non small cell cancer; granulocyte macrophage colony stimulating factor; editorial; tumor antigen; cancer research; prostate cancer; cancer inhibition; immunology; antigens, neoplasm; cancer vaccine; cancer vaccines; colon cancer; tumor antigens; melanoma antigen 3; ny eso 1 antigen; montanide isa 51; cancer immunization; clinical research; malignant neoplastic disease; immunomodulation; human immunodeficiency virus; mucin 1; immunological monitoring; kidney cancer; provenge; vaccine production; cytotoxic t lymphocyte antigen 4; granulocyte macrophage colony stimulating factor vaccine; immunosurveillance; cost; clinical trials; monitoring, immunologic; hiv infections; hiv; drug industry; ny-eso-1; cancer immunology; tumor escape; cancer immunosurveillance; human immunodeficiency virus vaccine; immunologic monitoring; oncophage; stimuvax; trovax; aids vaccines |
| Journal Title: | Cancer Immunity |
| Volume: | 8 |
| Issue: | SUPPL. 1 |
| ISSN: | 1424-9634 |
| Publisher: | Academy of Cancer Immunology |
| Date Published: | 2008-03-12 |
| Start Page: | 1 |
| Language: | English |
| PUBMED: | 18333603 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 28" - "Export Date: 17 November 2011" - "Source: Scopus" |
