NY-ESO-1: Review of an immunogenic tumor antigen Journal Article
| Authors: | Gnjatic, S.; Nishikawa, H.; Jungbluth, A. A.; Gure, A. O.; Ritter, G.; Jager, E.; Knuth, A.; Chen, Y.; Old, L. J.; Tew, K. D.; Fisher, P. B.; Vande Woude, G. F.; Klein, G. |
| Article Title: | NY-ESO-1: Review of an immunogenic tumor antigen |
| Title Series: | Advances in Cancer Research |
| Abstract: | In the 9 years since its discovery, cancer-testis antigen NY-ESO-1 has made one of the fastest transitions from molecular, cellular, and immunological description to vaccine and immunotherapy candidate, already tested in various formulations in more than 30 clinical trials worldwide. Its main characteristic resides in its capacity to elicit spontaneous antibody and T-cell responses in a proportion of cancer patients. An overview of immunological findings and immunotherapeutic approaches with NY-ESO-1, as well the role of regulation in NY-ESO-1 immunogenicity, is presented here. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | immunohistochemistry; clinical trial; review; drug efficacy; liver cell carcinoma; nonhuman; cancer patient; pancreas cancer; cancer staging; cancer diagnosis; neoplasms; antigen expression; cd8+ t lymphocyte; gene; cancer immunotherapy; cancer prevention; melanoma; apoptosis; multiple myeloma; ovary cancer; breast cancer; gene expression; dendritic cell; lung non small cell cancer; tumor markers, biological; membrane proteins; rna interference; in vitro study; cell line, tumor; bladder cancer; tumor antigen; immunoregulation; prostate cancer; gene mapping; gene expression regulation, neoplastic; regulatory t lymphocyte; amino acid sequence; antigens, neoplasm; gamma interferon; immunoglobulin g; cancer vaccine; head and neck cancer; cancer testis antigen; ny eso 1 antigen; immunogenicity; antibody response; antigen recognition; cancer immunization; cd4+ t lymphocyte; vaccination; recombinant protein; tumor cell; stomach cancer; tumor immunity; x chromosome; pregnancy; dna vaccine; virus recombinant; synovial sarcoma; cytokine release; esophagus cancer; humoral immunity; lymphocytes; chromosome analysis; transitional cell carcinoma; clinical trials; gene location; hla a2 antigen; vaccinia; immunoglobulin a; acrosome; cancer testis antigen ny eso 1 gene; chromosome xq; fowlpox virus; sex role |
| Journal Title: | Advances in Cancer Research |
| Volume: | 95 |
| ISSN: | 0065-230X |
| Publisher: | Academic Press, Elsevier Inc |
| Date Published: | 2006-01-01 |
| Start Page: | 1 |
| End Page: | 30 |
| Language: | English |
| DOI: | 10.1016/s0065-230x(06)95001-5 |
| PUBMED: | 16860654 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Chapter in "Advances in Cancer Research" (ISBN: 978-0-12-006695-7) --- - "Cited By (since 1996): 95" - "Export Date: 4 June 2012" - "CODEN: ACRSA" - "Source: Scopus" |
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