Myelodysplastic syndromes Journal Article
| Author: | Nimer, S. D. |
| Article Title: | Myelodysplastic syndromes |
| Abstract: | There has been a remarkable explosion of knowledge into the molecular defects that underlie the acute and chronic leukemias, leading to the introduction of targeted therapies that can block key cellular events essential for the viability of the leukemic cell. Our understanding of the pathogenesis of the myelodysplastic syndromes (MDSs) has lagged behind, at least in part, because they represent a more heterogeneous group of disorders. The significant immunologic abnormalities described in this disease, coupled with the admixture of MDS stem or progenitor cells within the myriad types of dysplastic and normal cells in the bone marrow and peripheral blood, have made it difficult to molecularly characterize and model MDS. The recent availability of several, effective (ie, FDA-approved) therapies for MDS and newly described mouse models that mimic aspects of the human disease provide an opportune moment to try to leverage this new knowledge into a better understanding of and better therapies for MDS. © 2008 by The American Society of Hematology. |
| Keywords: | cancer chemotherapy; cancer survival; acute granulocytic leukemia; gene mutation; gene deletion; mutation; lenalidomide; clinical feature; clinical trial; neutropenia; review; nonhuman; animal; animals; imatinib; multiple cycle treatment; gene expression; classification; erythropoietin; bone marrow; thrombocytopenia; pathology; stem cell; drug delivery systems; myelodysplastic syndrome; drug mechanism; histone; blood transfusion; 5 aza 2' deoxycytidine; drug therapy; drug delivery system; azacitidine; protein methylation; myelodysplastic syndromes; chromosome 20q; chromosome 7q; refractory anemia; novel erythropoiesis stimulating protein; chromosome 5q; refractory anemia with excess blasts; refractory anemia with ringed sideroblasts |
| Journal Title: | Blood |
| Volume: | 111 |
| Issue: | 10 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2008-05-15 |
| Start Page: | 4841 |
| End Page: | 4851 |
| Language: | English |
| DOI: | 10.1182/blood-2007-08-078139 |
| PUBMED: | 18467609 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 95" - "Export Date: 17 November 2011" - "CODEN: BLOOA" - "Source: Scopus" |
