Molecular biology of myelodysplastic syndromes Journal Article
| Authors: | Shih, A. H.; Levine, R. L. |
| Article Title: | Molecular biology of myelodysplastic syndromes |
| Abstract: | Myelodysplastic syndromes (MDS) are a group of clonal hematopoetic disorders marked by ineffective hematopoiesis, peripheral cytopenias, and an increased risk of transformation to acute myeloid leukemia. Multiple processes govern hematopoietic progenitor proliferation and natural differentiation into mature myeloid elements. Molecular events that disrupt any of these processes have the potential to lead to ineffective hematopoiesis and an MDS phenotype. Recent advances in genomic analysis have identified a number of new genes that may be involved. The molecular description of MDS will lead to better understanding, classification, and treatment of this disease. © 2011 Elsevier Inc. All rights reserved. |
| Keywords: | signal transduction; protein expression; protein phosphorylation; unclassified drug; acute granulocytic leukemia; histone deacetylase inhibitor; janus kinase 2; disease classification; nonhuman; protein function; cell proliferation; phenotype; cell differentiation; protein p53; dna methylation; transcription factors; myelodysplastic syndrome; hybrid protein; epigenetics; epigenesis, genetic; membrane protein; hematopoiesis; 5 aza 2' deoxycytidine; bone marrow cell; hematopoietic stem cell; molecular biology; cbl protein; stem cell niche; retinoic acid; cytopenia; azacitidine; myelodysplastic syndromes; polycomb group protein; protein tet2; transcription factor runx1; transcription factor ezh2; oncogene n ras; histone modification; molecular targeted therapy; janus kinase 1; janus kinase 3; additional sex comb like 1; cytokine receptor antagonist; flt 3 inhibitor; protein evi1 mds1 |
| Journal Title: | Seminars in Oncology |
| Volume: | 38 |
| Issue: | 5 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-10-01 |
| Start Page: | 613 |
| End Page: | 620 |
| Language: | English |
| DOI: | 10.1053/j.seminoncol.2011.04.013 |
| PROVIDER: | scopus |
| PMCID: | PMC3183432 |
| PUBMED: | 21943667 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 November 2011" - "CODEN: SOLGA" - "Source: Scopus" |
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