Strategies to advance translational research into brain barriers Journal Article


Authors: Neuwelt, E.; Abbott, N. J.; Abrey, L.; Banks, W. A.; Blakley, B.; Davis, T.; Engelhardt, B.; Grammas, P.; Nedergaard, M.; Nutt, J.; Pardridge, W.; Rosenberg, G. A.; Smith, Q.; Drewes, L. R.
Article Title: Strategies to advance translational research into brain barriers
Abstract: There is a paucity of therapies for most neurological disorders-from rare lysosomal storage diseases to major public health concerns such as stroke and Alzheimer's disease. Advances in the targeting of drugs to the CNS are essential for the future success of neurotherapeutics; however, the delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by the blood-brain barrier, the blood-CSF barrier, or other specialised CNS barriers. These brain barriers are now recognised as a major obstacle to the treatment of most brain disorders. The challenge to deliver therapies to the CNS is formidable, and the solution will require concerted international efforts among academia, government, and industry. At a recent meeting of expert panels, essential and high-priority recommendations to propel brain barrier research forward in six topical areas were developed and these recommendations are presented here. © 2008 Elsevier Ltd. All rights reserved.
Keywords: pathogenesis; review; nonhuman; drug targeting; ibritumomab tiuxetan; brain tumor; antineoplastic agent; biomedical research; models, biological; opiate; brain injury; diagnostic imaging; drug design; carmustine; central nervous system; drug delivery systems; government; cytokine; brain; prostaglandin; medical research; glioblastoma; blood brain barrier; protein transport; blood-brain barrier; gene therapy; brain disease; brain diseases; cell migration; lipopolysaccharide; parkinson disease; encephalitis; natalizumab; multiple sclerosis; leukocyte; dopamine; biological transport; degenerative disease; drug delivery system; medical expert; brain lymphoma; industry; amyloid beta protein; blood retina barrier; choroid plexus; levodopa; blood cerebrospinal fluid barrier; blood nerve barrier; meninx; transcytosis
Journal Title: Lancet Neurology
Volume: 7
Issue: 1
ISSN: 1474-4422
Publisher: Elsevier Science, Inc.  
Date Published: 2008-01-01
Start Page: 84
End Page: 96
Language: English
DOI: 10.1016/s1474-4422(07)70326-5
PUBMED: 18093565
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 63" - "Export Date: 17 November 2011" - "CODEN: LNAEA" - "Source: Scopus"
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  1. Lauren E Abrey
    277 Abrey