Clonal hematopoiesis: Crossroads of aging, cardiovascular disease, and cancer: JACC Review Topic of the Week Journal Article


Authors: Libby, P.; Sidlow, R.; Lin, A. E.; Gupta, D.; Jones, L. W.; Moslehi, J.; Zeiher, A.; Jaiswal, S.; Schulz, C.; Blankstein, R.; Bolton, K. L.; Steensma, D.; Levine, R. L.; Ebert, B. L.
Article Title: Clonal hematopoiesis: Crossroads of aging, cardiovascular disease, and cancer: JACC Review Topic of the Week
Abstract: A novel, common, and potent cardiovascular risk factor has recently emerged: clonal hematopoiesis of indeterminate potential (CHIP). CHIP arises from somatic mutations in hematopoietic stem cells that yield clonal progeny of mutant leukocytes in blood. Individuals with CHIP have a doubled risk of coronary heart disease and ischemic stroke, and worsened heart failure outcomes independent of traditional cardiovascular risk factors. The recognition of CHIP as a nontraditional risk factor challenges specialists in hematology/oncology and cardiovascular medicine alike. Should we screen for CHIP? If so, in whom? How should we assess cardiovascular risk in people with CHIP? How should we manage the excess cardiovascular risk in the absence of an evidence base? This review explains CHIP, explores the clinical quandaries, strives to provide reasonable recommendations for the multidisciplinary management of cardiovascular risk in individuals with CHIP, and highlights current knowledge gaps. © 2019 American College of Cardiology Foundation
Keywords: leukemia; cardiovascular risk; leukocyte; cancer; cardio-oncology
Journal Title: Journal of the American College of Cardiology
Volume: 74
Issue: 4
ISSN: 0735-1097
Publisher: Elsevier Science, Inc.  
Date Published: 2019-07-30
Start Page: 567
End Page: 577
Language: English
DOI: 10.1016/j.jacc.2019.06.007
PROVIDER: scopus
PMCID: PMC6681657
PUBMED: 31345432
DOI/URL:
Notes: Review -- Export Date: 2 August 2019 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Ross Levine
    504 Levine
  2. Dipti Gupta
    28 Gupta
  3. Lee Winston Jones
    113 Jones
  4. Robert   Sidlow
    11 Sidlow
  5. Kelly Leigh Bolton
    5 Bolton