Sarcomas of the mandible Journal Article


Authors: Petrovic, I.; Ahmed, Z. U.; Hay, A.; Rosen, E. B.; Lu, C.; Hameed, M.; Shah, J. P.
Article Title: Sarcomas of the mandible
Abstract: Introduction: Sarcomas of the mandible are extremely rare tumors, with osteosarcoma being the most common, followed by Ewing's sarcoma. Materials and methods: A retrospective review of the clinical records, imaging studies, and pathology slides of patients with sarcoma of the mandible at a Tertiary Care Cancer Center from 1998 to 2014 was undertaken. The impact of neoadjuvant chemotherapy and postoperative radiotherapy with or without chemotherapy was studied, and factors impacting upon local control and disease-specific survival were analyzed. Results: Twenty-two patients were treated over the study period, comprising of 15 males and seven females. External swelling, intraoral growth, or facial numbness were the presenting symptoms. Eighteen patients had osteosarcoma and four had the Ewing's sarcoma. Nine patients received neoadjuvant chemotherapy. All but one patient underwent surgery. Eleven had negative margins, with 90% recurrence-free survival at 3 years, compared to 10 with positive or close margins, leading to 67% recurrence-free survival. None of the patients receiving neoadjuvant chemotherapy developed recurrence and all were alive at 3 years. The impact of postoperative radiotherapy or adjuvant chemotherapy was not statistically significant. Conclusions: Wide surgical resection with negative margins remains the hallmark of surgical treatment. © 2019 Wiley Periodicals, Inc.
Keywords: osteosarcoma; sarcoma; ewing's sarcoma; mandible tumors
Journal Title: Journal of Surgical Oncology
Volume: 120
Issue: 2
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 2019-08-01
Start Page: 109
End Page: 116
Language: English
DOI: 10.1002/jso.25477
PUBMED: 30993699
PROVIDER: scopus
PMCID: PMC6635012
DOI/URL:
Notes: Article -- Export Date: 2 August 2019 -- Source: Scopus
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MSK Authors
  1. Meera Hameed
    143 Hameed
  2. Jatin P Shah
    560 Shah
  3. Evan Blake Rosen
    16 Rosen
  4. Ashley Hay
    10 Hay
  5. Chuanyong Lu
    7 Lu
  6. Zain Uddin Ahmed
    4 Ahmed