Isthmus organizer for mesencephalon and metencephalon Journal Article
| Authors: | Nakamura, H.; Sato, T.; Suzuki-Hirano, A. |
| Article Title: | Isthmus organizer for mesencephalon and metencephalon |
| Abstract: | The vertebrate central nervous system is elaborated from a simple neural tube. Brain vesicles formation is the first sign of regionalization. Classical transplantation using quail and chick embryos revealed that the mesencephalon-metencephalon boundary (isthmus) functions as an organizer of the mesencephalon and metencephalon. Fgf8 is accepted as a main organizing molecule of the isthmus. Strong Fgf8 signal activates the Ras-ERK signaling pathway to differentiate the cerebellum. In this review, the historical background of the means of identifying the isthmus organizer and the molecular mechanisms of signal transduction for tectum and cerebellum differentiation is reviewed. © 2008 The Authors. |
| Keywords: | signal transduction; protein expression; review; nonhuman; animals; cerebellum; purkinje cell; reverse transcription polymerase chain reaction; models, biological; developmental biology; transcription factors; vertebrata; gene expression regulation, developmental; brain development; extracellular signal-regulated map kinases; mesencephalon; neural crest; ras proteins; thyroid gland; models, anatomic; rhombencephalon; brain function; brain region; wnt1 protein; neural tube; fibroblast growth factor 8; transcription factor otx2; tectum; chick embryo; fgf8; isthmus organizer; ras-erk pathway; optic tectum; quail; metencephalon; phasianidae |
| Journal Title: | Development Growth & Differentiation |
| Volume: | 50 |
| Issue: | SUPPL. 1 |
| ISSN: | 0012-1592 |
| Publisher: | Blackwell Publishing |
| Date Published: | 2008-06-01 |
| Start Page: | S113 |
| End Page: | S118 |
| Language: | English |
| DOI: | 10.1111/j.1440-169X.2008.00995.x |
| PUBMED: | 18494704 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 11" - "Export Date: 17 November 2011" - "CODEN: DGDFA" - "Source: Scopus" |
