Ras oncogene point mutations in bladder cancer resistant to cisplatin Journal Article
| Authors: | Wood, D. P. Jr; Anderson, A. E.; Fair, R.; Chaganti, R. S. K. |
| Article Title: | Ras oncogene point mutations in bladder cancer resistant to cisplatin |
| Abstract: | Bladder tumors respond to cisplatin-based chemotherapy in 68% of cases, but only 30% will have a durable response. Recent studies have suggested that ras point mutations may produce cisplatin drug resistance in cell lines. To determine the role of ras point mutations in human tumors resistant to cisplatin, we evaluated ten tumors exposed to cisplatin and eight untreated bladder tumors for ras point mutations. Using polymerase chain reaction DNA amplification and allele-specific oligohybridization, we found that only one of the ten treated tumors and none of the untreated tumors harbored a ras point mutation. We conclude that ras point mutations occur infrequently in untreated bladder tumors and do not appear to correlate with cisplatin drug resistance in vivo. © 1992 Springer-Verlag. |
| Keywords: | clinical article; human tissue; mutation; cisplatin; polymerase chain reaction; drug resistance; bladder neoplasms; genes, ras; point mutation; carcinoma, transitional cell; transitional cell carcinoma; oncogene ras; oligonucleotide probes; human; article; ras point mutations; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; cisplatin-resistant bladder cancer |
| Journal Title: | Urological Research |
| Volume: | 20 |
| Issue: | 4 |
| ISSN: | 0300-5623 |
| Publisher: | Springer |
| Date Published: | 1992-06-01 |
| Start Page: | 313 |
| End Page: | 316 |
| Language: | English |
| DOI: | 10.1007/bf00300267 |
| PUBMED: | 1509639 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
