A prospective randomized trial of single versus multiple drains in the axilla after lymphadenectomy Journal Article


Authors: Petrek, J. A.; Peters, M. M.; Cirrincione, C.; Thaler, H. T.
Article Title: A prospective randomized trial of single versus multiple drains in the axilla after lymphadenectomy
Abstract: Increasing duration and amount of postoperative fluid formation after axillary lymphadenectomy delays final healing. We postulated that multiple drains (instead of a single drain) might decrease postoperative fluid accumulation by their greater proximity to points of leakage. We randomized 65 women with clinical stage I or II carcinoma of the breast to single or multiple drains. They were stratified for axillary dissection or modified radical mastectomy. For axillary dissection, randomization to multiple drains meant placement of four catheters in the axilla, and randomized to the single drain, one catheter in the axilla. For modified radical mastectomy, the patients randomized to multiple drains received four catheters in the axilla and one catheter under the inferior flap; the patients randomized to single drains had one catheter in the axilla and one catheter under the inferior flap. All catheters exited separately. The two arms (single versus multiple drains) were determined to be homogeneous in other variables that may affect postoperative fluid formation - age, size of the breast, weight, height, obesity, presence of previous surgical biopsy, excision of pectoralis minor muscle, excision of thoracodorsal complex, level of axillary dissection, number of lymph nodes, number and proportion of positive lymph nodes and whether or not the dominant hand was on the side operated upon. Single versus multiple drains had no clinically significant effect on the amount or duration of drainage, as an inpatient or outpatient, or total. We recommend a single drain to the axilla after lymphadenectomy.
Keywords: adult; aged; aged, 80 and over; major clinical study; comparative study; postoperative care; cancer staging; lymph node dissection; lymph node excision; prospective studies; lymphadenectomy; mastectomy; breast neoplasms; postoperative complication; axillary lymph node; breast carcinoma; axilla; lymph node biopsy; drainage; body fluid; wound drainage; middle age; mastectomy, modified radical; suction drainage; human; female; priority journal; article
Journal Title: Surgery, Gynecology and Obstetrics
Volume: 175
Issue: 5
ISSN: 0039-6087
Publisher: American College of Surgeons  
Date Published: 1992-11-01
Start Page: 405
End Page: 409
Language: English
PUBMED: 1440167
PROVIDER: scopus
DOI/URL:
Notes: Source: Scopus
Citation Impact
MSK Authors
  1. Jeanne Ann Petrek
    91 Petrek
  2. Howard T Thaler
    245 Thaler
  3. Margaret M Peters
    5 Peters