5'-Hydrogenphosphonates and 5'-methylphosphonates of sugar modified pyrimidine nucleosides as potential anti-HIV-1 agents Journal Article
| Authors: | Krayevsky, A. A.; Tarussova, N. B.; Zhu, Q. Y.; Vidal, P.; Chou, T. C.; Baron, P.; Polsky, B.; Jiang, X. J.; Matulič-Adamič, J.; Rosenberg, I.; Watanabe, K. A. |
| Article Title: | 5'-Hydrogenphosphonates and 5'-methylphosphonates of sugar modified pyrimidine nucleosides as potential anti-HIV-1 agents |
| Abstract: | A number of nucleoside 5‘;-hydrogenphosphonates and nucleoside 5‘;-ioethylphosphonates were prepared, to study their ability to inhibit replication of HIV-1. Two compounds, the 5’-hydrogenphosphonate of 3’;-azido-3‘; -deoxythymidine (AZT-HP, IVc) and of 3‘; -deoxy-3‘; -fluorothymidine (FLT-HP, IVa), exhibit potent anti-HIV-1 activity with selectivity indices similar to or better than those of their parent nucleosides. © 1992, Taylor & Francis Group, LLC. All rights reserved. |
| Keywords: | unclassified drug; human cell; nonhuman; mass spectrometry; enzyme inhibition; cytotoxicity; drug synthesis; antivirus agent; virus replication; nuclear magnetic resonance; antiviral activity; human immunodeficiency virus 1; nucleoside; zidovudine; phosphonic acid derivative; 3' fluorothymidine; pyrimidine nucleoside; rna directed dna polymerase; article; zalcitabine; ultraviolet spectrophotometry; 2',3' dideoxyadenosine; 2',3' dideoxythymidine; 3' deoxy 3' fluorothymidine 5' hydrogenphosphonate; zidovudine 5' hydrogenphosphonate |
| Journal Title: | Nucleosides & Nucleotides |
| Volume: | 11 |
| Issue: | 2-4 |
| ISSN: | 0732-8311 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 1992-01-01 |
| Start Page: | 177 |
| End Page: | 196 |
| Language: | English |
| DOI: | 10.1080/07328319208021696 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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