Polypodium leucotomos extract inhibits glutathione oxidation and prevents Langerhans cell depletion induced by UVB/UVA radiation in a hairless rat model Journal Article
| Authors: | Mulero, M.; Rodríguez-yanes, E.; Nogués, M. R.; Giralt, M.; Romeu, M.; Gonzalez, S.; Mallol, J. |
| Article Title: | Polypodium leucotomos extract inhibits glutathione oxidation and prevents Langerhans cell depletion induced by UVB/UVA radiation in a hairless rat model |
| Abstract: | In this report, we have addressed the effect of oral administration of a hydrophilic extract of the fern Polypodium leucotomos (PL) on the deleterious effects of ultraviolet radiation (UVR) on the levels of epidermal and plasmatic antioxidants in hairless rats. We have found that pretreatment with PL effectively reduced glutathione oxidation in both blood and epidermis, suggesting a potent systemic antioxidant effect. In addition, PL inhibited UVR-mediated Langerhans cell (LC) depletion. Our results demonstrate the efficacy of PL as an oral antioxidant and photoimmunoprotective agent and support its employment as a complement to topical sunscreens. © Journal compilation © 2008 Blackwell Munksgaard. |
| Keywords: | controlled study; drug efficacy; nonhuman; animal cell; animals; animal tissue; sunscreen; epidermis; animal experiment; animal model; blood analysis; rat; radiation-protective agents; cell count; rats; plant extracts; antioxidant; antioxidants; antioxidant activity; ultraviolet a radiation; ultraviolet b radiation; ultraviolet rays; administration, oral; alopecia; cell protection; oxidation; oxidation-reduction; glutathione; erythrocytes; polypodium leucotomos extract; polypodium; langerhans cell; langerhans cells; photoprotection; catalase; natural plant extract; hairless rat; glutathione disulfide; rats, hairless |
| Journal Title: | Experimental Dermatology |
| Volume: | 17 |
| Issue: | 8 |
| ISSN: | 0906-6705 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2008-08-01 |
| Start Page: | 653 |
| End Page: | 658 |
| Language: | English |
| DOI: | 10.1111/j.1600-0625.2007.00684.x |
| PUBMED: | 18312382 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "CODEN: EXDEE" - "Source: Scopus" |
