Neurotropic melanoma. A case report and review of the literature Journal Article
| Authors: | Mack, E. E.; Gomez, E. C. |
| Article Title: | Neurotropic melanoma. A case report and review of the literature |
| Abstract: | Neurotropic melanoma is a rare tumor with a biphasic growth pattern associated with a change in morphology from melanocytic features toward Schwann cell features. The tumor thereby develops a capacity for infiltrating nerves which may result in clinically evident cranial neuropathies, most commonly of the fifth and seventh cranial nerves. The histology of this lesion is difficult to interpret; it often erroneously appears fibrous in origin and may be considered to be benign. Despite this benign appearance histologically, the tumor behaves aggressively with multiple local recurrences and possible CNS invasion by either direct perineural growth or distant metastases. We review the literature of neurotropic melanomas and report a 46th case which describes a typical course with neural invasion. Although a rare cause of cranial neuropathies, the neurologist should consider this entity in the differential diagnosis and the history of a recurrent skin lesion of the face should be sought whenever examining such a patient. © 1992 Kluwer Academic Publishers. |
| Keywords: | adult; aged; aged, 80 and over; case report; doxorubicin; chemotherapy, adjuvant; combined modality therapy; brain neoplasms; melanoma; computer assisted tomography; neoplasm recurrence, local; skin neoplasms; neuropathy; antineoplastic combined chemotherapy protocols; tumor markers, biological; cyclophosphamide; vincristine; cranial irradiation; diagnostic errors; organ specificity; neoplasm invasiveness; dermatofibroma; carcinoma, basal cell; neoplasms, multiple primary; cranial neuropathy; neuropathology; middle age; trigeminal nerve; neurotropism; neurotropic; human; male; female; article; lip neoplasms |
| Journal Title: | Journal of Neuro-Oncology |
| Volume: | 13 |
| Issue: | 2 |
| ISSN: | 0167-594X |
| Publisher: | Springer |
| Date Published: | 1992-06-01 |
| Start Page: | 165 |
| End Page: | 171 |
| Language: | English |
| DOI: | 10.1007/bf00172766 |
| PUBMED: | 1331344 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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