Subregional mapping of 13 single-copy genes on the long arm of chromosome 12 by fluorescence in situ hybridization Journal Article

  


Authors: Mathew, S.; Murty, V. V. V. S.; Hunziker, W.; Chaganti, R. S. K.
Article Title: Subregional mapping of 13 single-copy genes on the long arm of chromosome 12 by fluorescence in situ hybridization
Abstract: Subregional localization of 13 single-copy DNA sequences previously assigned to the long arm of chromosome 12 has been performed using the fluorescence in situ hybridization (FISH) technique. The following order is suggested for the 13 mapped genes: cen → COL2A1 → (VDR-D12S15) → (D12S17-D12S4-D12S14-D12S6) → D12S8 → (IAPP-MGF-D12S7-D12S12) → IGF1 → qter. Eight of the mapped genes clustered at two regions, one at 12q13 (D12S17-D12S4-D12S14-D12S6) and the other at 12q22 (IAPP-MGF-D12S7-D12S12). Our results show that single-copy DNA sequences as small as 500 bp can be successfully mapped by FISH. © 1992 Academic Press, Inc. All rights reserved.
Keywords: human cell; in situ hybridization, fluorescence; gene mapping; fluorescence in situ hybridization; chromosome 12q; gene location; chromosome mapping; chromosomes, human, pair 12; human; article; support, u.s. gov't, p.h.s.; dna probe
Journal Title: Genomics
Volume: 14
Issue: 3
ISSN: 0888-7543
Publisher: Elsevier Inc.  
Date Published: 1992-11-01
Start Page: 775
End Page: 779
Language: English
DOI: 10.1016/s0888-7543(05)80184-3
PUBMED: 1427906
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026539871&doi=10.1016%2fS0888-7543%2805%2980184-3&partnerID=40&md5=ecf3a89f1d726fec949a4e7241e56ef0
Notes: Article -- Export Date: 30 July 2019 -- Source: Scopus
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MSK Authors
  1. Raju S K Chaganti
    391 Chaganti
  2. Vundavalli V. V. S. Murty
    53 Murty
  3. Susan Mathew
    26 Mathew
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