Detection of cell-cycle stage by fluorescence in situ hybridization: Its application in human interphase cytogenetics Journal Article

  


Authors: Mukherjee, A. B.; Murty, V. V. V. S.; Chaganti, R. S. K.
Article Title: Detection of cell-cycle stage by fluorescence in situ hybridization: Its application in human interphase cytogenetics
Abstract: Distinct cell-cycle-dependent changes in the conformation of centromeric chromatin in a specific human chromosome containing a-satellite DNA have been demonstrated by fluorescence in situ hybridization (FISH). This method, based upon specific FISH signal morphology, allows simultaneous analysis of chromosomal aneuploidy and detection of specific cell-cycle stage(s) of human tumor and/or normal cell populations in a single preparation of interphase cells. This interphase cytogenetic procedure might prove useful for both basic and clinical research involving human cells. © 1992 S. Karger AG, Basel.
Keywords: human cell; cell cycle; cell line; spectrometry, fluorescence; cytogenetics; tumor cells, cultured; in situ hybridization; fluorescence in situ hybridization; kinetics; chromosome analysis; karyotyping; aneuploidy; centromere; interphase; chromosomes, human, pair 12; human; male; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.
Journal Title: Cytogenetics and Cell Genetics
Volume: 61
Issue: 2
ISSN: 0301-0171
Publisher: S. Karger AG  
Date Published: 1992-01-01
Start Page: 91
End Page: 94
Language: English
DOI: 10.1159/000133378
PUBMED: 1395732
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026783868&doi=10.1159%2f000133378&partnerID=40&md5=63c17f9ba34716eb1e24cc0575b95762
Notes: Article -- Export Date: 30 July 2019 -- Source: Scopus
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MSK Authors
  1. Raju S K Chaganti
    391 Chaganti
  2. Vundavalli V. V. S. Murty
    53 Murty
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