Acute arterial thrombosis after escalated‐dose methotrexate, vinblastine, doxorubicin, and cisplatin chemotherapy with recombinant granulocyte colony‐stimulating factor: A possible new recombinant granulocyte colony‐stimulating factor toxicity Journal Article

  

Authors:	Conti, J. A.; Scher, H. I.
Article Title:	Acute arterial thrombosis after escalated‐dose methotrexate, vinblastine, doxorubicin, and cisplatin chemotherapy with recombinant granulocyte colony‐stimulating factor: A possible new recombinant granulocyte colony‐stimulating factor toxicity
Abstract:	Combination chemotherapy with a regimen of methotrexate, vinblastine, doxorubicin, and cisplatin (M‐VAC) has produced long‐term survival times in a significant proportion of patients with advanced nodal and meta‐static urothelial tumors. The availability of the colony‐stimulating factors has spurred interest in studies evaluating escalated dosing schedules of M‐VAC in an attempt to improve major response rates and overall survival. More frequent use of the colony‐stimulating factors, however, in this and other settings may be associated with unrecognized side effects. The authors report a case of arterial thrombosis in a 69‐year‐old man receiving recombinant granulocyte colony‐stimulating factor (rhG‐CSF) and escalated‐dose M‐VAC for treatment of a transitional cell carcinoma of the bladder. Incidents of venous thrombosis have been reported previously with the use of colony‐stimulating factors, but, to the knowledge of the authors, this case represents the first report of an arterial thrombosis occurring in a patient receiving rhG‐CSF. Copyright © 1992 American Cancer Society
Keywords:	cancer survival; aged; case report; cisplatin; doxorubicin; chemotherapy; methotrexate; antineoplastic combined chemotherapy protocols; combination chemotherapy; bladder tumor; vinblastine; vein thrombosis; atherosclerosis; thrombosis; recombinant proteins; urogenital tract tumor; bladder neoplasms; recombinant granulocyte colony stimulating factor; carcinoma, transitional cell; transitional cell carcinoma; leukocytosis; granulocyte colony-stimulating factor; artery thrombosis; hypercoagulability; subcutaneous drug administration; arterial thrombosis; human; male; priority journal; article; hypercoagulable state; support, u.s. gov't, p.h.s.; colony‐stimulating factors; malignant bladder neoplasms
Journal Title:	Cancer
Volume:	70
Issue:	11
ISSN:	0008-543X
Publisher:	Wiley Blackwell
Date Published:	1992-12-01
Start Page:	2699
End Page:	2702
Language:	English
DOI:	10.1002/1097-0142(19921201)70:11<2699::Aid-cncr2820701122>3.0.Co;2-c
PUBMED:	1384952
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026485559&doi=10.1002%2f1097-0142%2819921201%2970%3a11%3c2699%3a%3aAID-CNCR2820701122%3e3.0.CO%3b2-C&partnerID=40&md5=012a14998fba86ceffb3784b2a6c93c8
Notes:	Article -- Export Date: 30 July 2019 -- Source: Scopus

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