Treatment of unresectable primary liver cancer with intrahepatic fluorodeoxyuridine and mitomycin C through an implantable pump Journal Article

  

Authors:	Atiq, O. T.; Kemeny, N.; Niedzwiecki, D.; Botet, J.
Article Title:	Treatment of unresectable primary liver cancer with intrahepatic fluorodeoxyuridine and mitomycin C through an implantable pump
Abstract:	Ten patients with unresectable primary liver cancer, eight of whom had elevated serum alpha‐fetoprotein levels, were treated with intrahepatic fluorodeoxyuridine (FUDR) and mitomycin C administered through an implantable pump. Four patients had a partial response, and two had a minor response. The median survival from initiation of treatment was 14.5 months (range, 2 to 32 months), with patients receiving therapy for a median of 11.2 months. In general, the therapy was well tolerated; only one patient had treatment‐related biliary sclerosis. In conclusion, the combination of intrahepatic FUDR and mitomycin C was an effective palliative regimen for unresectable primary liver cancer, even in the presence of elevated serum alpha‐fetoprotein levels. Further studies are needed to confirm these findings and compare this regimen with other methods of treatment for hepatocellular carcinoma. Cancer 1992; 69:920–924. Copyright © 1992 American Cancer Society
Keywords:	adolescent; adult; cancer survival; clinical article; aged; survival analysis; implant; cancer combination chemotherapy; liver neoplasms; laparotomy; palliative care; leukopenia; thrombocytopenia; antineoplastic combined chemotherapy protocols; creatinine; continuous infusion; abdominal pain; bilirubin; survival time; intraarterial drug administration; mitomycin c; liver cancer; liver enzyme; mitomycin; floxuridine; hepatic artery; alpha fetoprotein; infusion pumps, implantable; middle age; infusion pump; artery catheter; human; male; female; priority journal; article
Journal Title:	Cancer
Volume:	69
Issue:	4
ISSN:	0008-543X
Publisher:	Wiley Blackwell
Date Published:	1992-02-15
Start Page:	920
End Page:	924
Language:	English
DOI:	10.1002/1097-0142(19920215)69:4<920::Aid-cncr2820690414>3.0.Co;2-y
PUBMED:	1370918
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026543543&doi=10.1002%2f1097-0142%2819920215%2969%3a4%3c920%3a%3aAID-CNCR2820690414%3e3.0.CO%3b2-Y&partnerID=40&md5=0dff25869162c86801d649710c918606
Notes:	Article -- Export Date: 30 July 2019 -- Source: Scopus

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