Intrahepatic mitomycin C as a salvage treatment for patients with hepatic metastases from colorectal carcinoma Journal Article

  


Authors: Schneider, A.; Kemeny, N.; Chapman, D.; Niedzwiecki, D.; Oderman, P.
Article Title: Intrahepatic mitomycin C as a salvage treatment for patients with hepatic metastases from colorectal carcinoma
Abstract: Sixty‐four evaluable patients with hepatic metastases from colorectal carcinoma, who did not have evidence of extrahepatic disease, were treated with intrahepatic (IH) mitomycin C (M) after disease progression or intolerance to treatment with IH fluorodeoxyuridine (FUDR). Eleven patients (17%) had a partial response (PR) to IH M and ten (16%) patients had stable disease. Patients who responded to IH FUDR were more likely to respond to IH M when compared with those who progressed on IH FUDR (47% versus 13%, respectively; P = 0.013). Those who were switched to IH M because of hepatotoxicity on IH FUDR also were more likely to respond to IH M than those who were switched because of progression on IH FUDR (75% versus 27%, respectively; P = 0.022). Baseline laboratory values, the percent of tumorous liver involvement, prior history of systemic chemotherapy, and the interval from diagnosis to initiation of IH M did not help predict response. Toxicity was mild and well tolerated. The overall median survival time of the 64 evaluable patients was 9.0 months from the start of IH M therapy. We conclude that IH M has some salvage benefit in patients with hepatic metastases. Copyright © 1989 American Cancer Society
Keywords: major clinical study; fluorouracil; liver neoplasms; liver toxicity; thrombocytopenia; colorectal carcinoma; colorectal neoplasms; liver metastasis; remission induction; sepsis; mitomycin c; leukocyte count; mitomycin; floxuridine; platelet count; mitomycins; disseminated intravascular clotting; human; male; female; priority journal
Journal Title: Cancer
Volume: 64
Issue: 11
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 1989-12-01
Start Page: 2203
End Page: 2206
Language: English
DOI: 10.1002/1097-0142(19891201)64:11<2203::Aid-cncr2820641103>3.0.Co;2-o
PUBMED: 2529960
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024426521&doi=10.1002%2f1097-0142%2819891201%2964%3a11%3c2203%3a%3aAID-CNCR2820641103%3e3.0.CO%3b2-O&partnerID=40&md5=9b2b873872796743a612edc57c72d921
Notes: Article -- Source: Scopus
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MSK Authors
  1. Nancy Kemeny
    543 Kemeny
  2. Donna Niedzwiecki
    61 Niedzwiecki
  3. Douglass S. Chapman
    35 Chapman
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