The indications for elective treatment of the neck in cancer of the major salivary glands Journal Article
| Authors: | Armstrong, J. G.; Harrison, L. B.; Thaler, H. T.; Friedlander‐Klar, H.; Fass, D. E.; Zelefsky, M. J.; Shah, J. P.; Strong, E. W.; Spiro, R. H. |
| Article Title: | The indications for elective treatment of the neck in cancer of the major salivary glands |
| Abstract: | To define the indications for elective neck treatment, the cases of 474 previously untreated patients were reviewed who had locally confined major salivary gland cancers treated between 1939 and 1982, Clinically positive nodes were present in 14% (67 of 474). Overall, clinically occult, pathologically positive nodes occurred in 12% (47 of 407). By univariate analysis, several factors appeared to predict the risk of occult metastases; however, multivariate analysis revealed that only size and grade were significant risk factors. Tumors 4 cm or more in size had a 20% (32 of 164) risk of occult metastases compared with a 4% (nine of 220) risk for smaller tumors [P < 0.00001). High‐grade tumors (regardless of histologic type) had a 49% (29 of 59) risk of occult metastases compared with a 7% (15 of 221) risk for intermediate‐grade or low‐grade tumors [P < 0.00001). In view of the low frequency of occult metastases in the entire group, routine elective treatment of the neck is not recommended. High‐grade tumors and larger tumors have a high rate of occult neck metastases, and treatment should be considered in this group. Copyright © 1992 American Cancer Society |
| Keywords: | treatment outcome; retrospective studies; major clinical study; comparative study; lymph node metastasis; lymphatic metastasis; lymph node excision; risk factors; histology; multivariate analysis; salivary gland neoplasms; neck; salivary gland cancer; cervical lymph node; analysis of variance; parotid neoplasms; human; priority journal; article; submandibular gland neoplasms; sublingual gland neoplasms |
| Journal Title: | Cancer |
| Volume: | 69 |
| Issue: | 3 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1992-02-01 |
| Start Page: | 615 |
| End Page: | 619 |
| Language: | English |
| DOI: | 10.1002/1097-0142(19920201)69:3<615::Aid-cncr2820690303>3.0.Co;2-9 |
| PUBMED: | 1730113 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work