Use of propofol for the prevention of chemotherapy-induced nausea and emesis in oncology patients Journal Article

  


Authors: Scher, C. S.; Amar, D.; McDowall, R. H.; Barst, S. M.
Article Title: Use of propofol for the prevention of chemotherapy-induced nausea and emesis in oncology patients
Abstract: Nausea and vomiting associated with antineoplastic chemotherapy are distressing and may keep patients from complying with chemotherapy protocols. No drug has emerged among many as an effective antiemetic. It has been speculated that propofol may have intrinsic antiemetic properties. We report the use of low-dose continuous infusion propofol in three oncology patients to treat chemotherapy-associated nausea and vomiting. A bolus of 0.1 mg · kg-1 followed by a continuous infusion of 1 mg · kg-1 hr-1 was effective in both prevention and treatment of nausea and vomiting. All three patients were alert, reported low nausea scores by visual analogue scale, and had no episodes of vomiting. When the infusion was discontinued, nausea and vomiting were noted in two patients. Propofol, given in a subanaesthetic infusion, was safe and effective as an antiemetic in these three patients. © 1992 Canadian Anesthesiologists.
Keywords: osteosarcoma; adolescent; adult; bone neoplasms; case report; antineoplastic agents; methotrexate; antineoplastic agent; nausea; vomiting; propofol; cyclophosphamide; ifosfamide; sarcoma; antiemetics; infusions, intravenous; intravenous drug administration; injections, intravenous; human; male; female; priority journal; article; anaesthetic, intravenous: propofol; vomiting: antiemetics, incidence, nausea
Journal Title: Canadian Journal of Anesthesia/Journal Canadien d'Anesthesie
Volume: 39
Issue: 2
ISSN: 0832-610X
Publisher: Springer  
Date Published: 1992-02-01
Start Page: 170
End Page: 172
Language: English
DOI: 10.1007/bf03008650
PUBMED: 1544199
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026590710&doi=10.1007%2fBF03008650&partnerID=40&md5=7484da0fb941aa62a48a117ad203f3d5
Notes: Article -- Export Date: 30 July 2019 -- Source: Scopus
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MSK Authors
  1. David Amar
    137 Amar
  2. Robert H McDowall
    9 McDowall
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