Dose-ranging evaluation of the substituted benzamide dazopride when used as an antiemetic in patients receiving anticancer chemotherapy Journal Article

  

Authors:	Grant, S. C.; Kris, M. G.; Gralla, R. J.; Clark, R. A.; Tyson, L. B.
Article Title:	Dose-ranging evaluation of the substituted benzamide dazopride when used as an antiemetic in patients receiving anticancer chemotherapy
Abstract:	Dazopride, a substituted benzamide structurally related to metoclopramide, is a potent gastric prokinetic agent that prevents cisplatin-induced emesis in animals. Unlike metoclopramide, dazopride has no effect on dopamine receptors and therefore should not produce extrapyramidal side effects. In this dose-ranging trial, 23 patients with cancer receiving chemotherapy known to produce nausea and vomiting received three i.v. infusions of dazopride every 2 h beginning 30 min before the chemotherapy. Seven dose levels were explored ranging from 0.5 to 4.0 mg/kg in each of the three infusions. Toxicities were mild and included sedation, dizziness, visual disturbances, and headaches. All side effects were transient and were not dose-related. Antiemetic effects were observed. Dazopride can be safely given on this schedule at doses of up to 4.0 mg/kg to patients receiving chemotherapy. On the basis of the results of this trial, further studies of this agent are warranted. © 1993 Springer-Verlag.
Keywords:	adult; cancer chemotherapy; clinical article; controlled study; treatment outcome; aged; cisplatin; doxorubicin; methotrexate; antineoplastic agent; neoplasms; breast cancer; nausea; vomiting; antineoplastic combined chemotherapy protocols; lung cancer; cyclophosphamide; vincristine; lomustine; vinblastine; acute leukemia; dactinomycin; bleomycin; antiemetic agent; antiemetics; headache; mitomycin; testis cancer; visual disorder; intravenous drug administration; middle age; vertigo; benzamide derivative; benzamides; drug evaluation; antiemetic activity; human; male; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; dazopride
Journal Title:	Cancer Chemotherapy and Pharmacology
Volume:	31
Issue:	6
ISSN:	0344-5704
Publisher:	Springer
Date Published:	1993-11-01
Start Page:	442
End Page:	444
Language:	English
DOI:	10.1007/bf00685032
PUBMED:	8453682
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027535999&doi=10.1007%2fBF00685032&partnerID=40&md5=7aacd60053064ceb62fc0402fd4a88c3
Notes:	Source: Scopus

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