Regulation and modulation of skin melanogenesis Journal Article
| Authors: | Middelkamp-Hup, M. A.; Bos, J. D.; Gonzalez, S.; Westerhof, W. |
| Article Title: | Regulation and modulation of skin melanogenesis |
| Abstract: | Skin pigmentation is a very important visible and recognizable characteristic of human beings. Much research is performed in this area to increase our understanding of melanogenesis, a complex multistep process regulated at gene expression level and by post-translational mechanisms involving different enzymes and substrates. The aim of this review is to provide an overview of the current knowledge on the process of skin melanogenesis. First, we will discuss the melanosome, the organelle where melanogenesis takes place, and then focus on the process of melanogenesis itself, with a description of its most important pathways leading to skin pigmentation. Finally, two major melanogenesis modulators, UV radiation and oxidative stress, will be discussed. © 2008 Future Drugs Ltd. |
| Keywords: | signal transduction; protein expression; protein phosphorylation; review; nonhuman; skin manifestation; ultraviolet radiation; dna damage; gene expression; skin pigmentation; melanocyte; genetic variability; enzyme activation; enzyme activity; phosphatidylinositol 3 kinase; pigmentation; tyrosine 3 monooxygenase; erythema; reactive oxygen metabolite; oxidative stress; microphthalmia associated transcription factor; melanocortin 1 receptor; melanogenesis; sunburn; chromatophore; cyclic amp dependent protein kinase; 8 hydroxydeoxyguanosine; protein kinase c beta; hormone receptor interaction; corticotropin; proopiomelanocortin; light absorption; uv radiation; eumelanin; melanosome; alpha intermedin; phenylalanine 4 monooxygenase; pheomelanin |
| Journal Title: | Expert Review of Dermatology |
| Volume: | 3 |
| Issue: | 2 |
| ISSN: | 1746-9872 |
| Publisher: | Informa Healthcare |
| Date Published: | 2008-04-01 |
| Start Page: | 179 |
| End Page: | 186 |
| Language: | English |
| DOI: | 10.1586/17469872.3.2.179 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 17 November 2011" - "Source: Scopus" |
